Tobradex

Tobradex

tobramycin + dexamethasone

Manufacturer:

Novartis

Distributor:

DKSH
Concise Prescribing Info
Contents
Tobramycin 0.3%, dexamethasone 0.1%
Indications/Uses
Steroid-responsive inflammatory ocular condition for which corticosteroid is indicated & where superficial bacterial ocular infection or risk of bacterial ocular infection exists.
Dosage/Direction for Use
Ophth susp 1-2 drops into conjunctival sac every 4-6 hr, may be increased to 1-2 drops every 2 hr during initial 24-48 hr. Ophth oint Apply ½ inch ribbon into conjunctival sac up to tds-qds. May be used at bedtime in conjunction w/ ophth drops.
Contraindications
Hypersensitivity. Herpes simplex keratitis. Vaccinia, varicella, other corneal & conjunctival viral infections. Fungal diseases of ocular structures or untreated parasitic eye infections. Mycobacterial ocular infections.
Special Precautions
Discontinue use if hypersensitivity, fungal infection or superinfection occurs. Cross-hypersensitivity to other aminoglycosides. Predisposed patients eg, diabetes & patients treated w/ CYP3A4 inhibitors. Known or suspected neuromuscular disorders eg, myasthenia gravis or Parkinson's disease; Cushing's syndrome &/or adrenal suppression; disease causing cornea or sclera thinning. Overgrowth of non-susceptible organisms. May aggravate muscle weakness, slow corneal wound healing & mask clinical signs of infections. Concomitant use w/ systemic aminoglycosides; topical NSAIDs; CYP3A4 inhibitors. May cause eye irritation due to benzalkonium Cl. Avoid contact w/ soft contact lens; container tip. Prolonged use. Avoid abrupt discontinuation. Remove contact lens prior to application & wait 15 min before reinsertion. Allow 5 min interval w/ concomitant use of other topical ocular medicinal products. May affect ability to drive & use machines. Not recommended during pregnancy. Lactation. Not to be used in childn.
Adverse Reactions
Uncommonly, increased IOP, eye pain, pruritus & irritation, ocular discomfort.
Drug Interactions
Increased potential for corneal healing problems w/ topical NSAIDs. Increased systemic exposure w/ CYP3A4 inhibitors eg, ritonavir, cobicistat.
MIMS Class
Eye Antiseptics with Corticosteroids
ATC Classification
S01CA01 - dexamethasone and antiinfectives ; Belongs to the class of corticosteroids in combination with antiinfectives. Used in the treatment of eye diseases.
Presentation/Packing
Form
Tobradex ophth oint
Packing/Price
3.5 g x 1's
Form
Tobradex ophth susp
Packing/Price
5 mL x 1's
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