Trandate

Trandate

labetalol

Manufacturer:

Aspen

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Labetalol HCl
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Tab Mild, moderate or severe HTN & angina pectoris w/ coexisting HTN Initially 100 mg bd. Increase in dose at intervals of 2-14 days. Severe, refractory HTN 2,400 mg daily in 3 or 4 divided doses. HTN in pregnancy Initially 100 mg bd, increase at wkly intervals. Bolus inj Adult 50 mg IV for at least 1 min. If necessary, repeat at 5-min intervals until satisfactory response occurs. Max total dose of 200 mg. IV infusion Severe HTN in pregnancy Start infusion at the rate of 20 mg/hr & doubled every 30 min until a satisfactory response obtained or a dosage of 160 mg/hr is reached. HTN due to other causes Rate of infusion of 2 mg/min. Dose range: 50-200 mg. Hypotensive anaesth 10-20 mg IV. Hypertensive episodes following acute MI Start infusion at 15 mg/hr & gradually increased to a max of 120 mg/hr.
Administration
Should be taken with food.
Contraindications
2nd or 3rd degree heart block, cardiogenic shock, severe & prolonged hypotension or bradycardia. Asthma or a history of bronchospasm. In case of peripheral vasoconstriction suggests low cardiac output.
Special Precautions
History of severe anapylactic reaction. Peripheral vascular disease, 1st-degree AV block. May mask symptoms of hypoglycaemia in diabetic & thyrotoxicosis. History of poor cardiac reserve, concomitant w/ class I antiarrhythmics or verapamil Ca antagonists, ischaemic heart disease. May affect ability to drive or operate machinery. Hepatic impairment. Pregnancy & lactation.
Adverse Reactions
Hypersensitivity, postural hypotension, nasal congestion, positive antinuclear Ab unassociated w/ disease, nervous system disorders, blurred vision, nausea, difficulty in micturition, ejaculatory failure, tiredness, lethargy.
Drug Interactions
Reduced hypotensive effect in combination w/ prostaglandin synthetase inhibitors. Reduced uptake of metaiodobenzylguanidine (MIBG) radioisotopes. Enhanced effect of digoxin in reducing ventricular rate. May result to bradycardia & HTN in combination w/ adrenaline. Enhanced hypotensive effect of halothane. Increased incident of tremor w/ concomitant use of TCAs. Increased bioavailabiltiy in combination w/ cimetidine.
MIMS Class
ATC Classification
C07AG01 - labetalol ; Belongs to the class of alpha and beta blocking agents. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Trandate FC tab 100 mg
Packing/Price
50's
Form
Trandate inj 25 mg/5 mL
Packing/Price
5 × 1's
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