Trandate

Trandate Dosage/Direction for Use

labetalol

Manufacturer:

Aspen

Distributor:

Zuellig Pharma
Full Prescribing Info
Dosage/Direction for Use
Tablet: Posology: Labetalol tablets should be taken with food.
Populations: Adults: (See Table 2.)

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Paediatric population: Safety and efficacy in paediatric patients aged 0 to 18 years has not been established. No data are available.
Older people: In markets where a 50 mg tablet is available: For initiation of anti-hypertensive therapy, the usual starting dose is 100 mg orally twice daily. However, an initial dosage of 50 mg twice daily may be given.
In markets where a 50 mg tablet is not available: For initiation of anti-hypertensive therapy, the usual starting dose is 100 mg orally twice daily.
Satisfactory blood pressure control may be achieved with lower maintenance doses than those required by younger patients.
Patients with hepatic impairment: In patients with hepatic impairment, lower doses of the oral formulation may be required (see Precautions).
Injection: Posology: Labetalol injection is intended for i.v. use in hospitalised patients.
Populations: Adults: (See Table 3.)

Click on icon to see table/diagram/image

Paediatric population: The safety and efficacy of labetalol in paediatric patients aged 0 to 18 years have not been established. No data are available.
Method of Administration: Precautions to be taken before handling or administering the medicinal product: Patients should always receive the drug whilst in the supine or left lateral position.
Raising the patient into the upright position within 3 h of i.v. labetalol administration should be avoided since excessive postural hypotension may occur.
It is desirable to monitor the blood pressure and heart rate after injection and during infusion. In most patients, there is a small decrease in the heart rate; severe bradycardia is unusual but may be controlled by injecting atropine 1 to 2 mg intravenously.
Respiratory function should be observed particularly in patients with any known impairment.
Once the blood pressure has been adequately reduced by bolus injection or infusion, maintenance therapy with labetalol tablets should be substituted with a starting dose of 100 mg twice daily.
Labetalol injection has been administered to patients with uncontrolled hypertension already receiving other hypotensive agents, including beta-blocking drugs, without adverse effects.
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