Trandate Use In Pregnancy & Lactation





Zuellig Pharma
Full Prescribing Info
Use In Pregnancy & Lactation
Fertility: There are no data on the effects of labetalol on fertility.
Pregnancy: Based on experience during human pregnancy, labetalol is not expected to increase the risk of congenital malformations. Animal studies do not indicate teratogenicity. However toxicity on embryo-foetal development has been noted (see Pharmacology: Toxicology: Non-Clinical Information under Actions).
Due to the pharmacological action of alpha- and beta-adrenoceptor blockade, adverse effects on the foetus and neonate when used in the later stages of pregnancy (bradycardia, hypotension, respiratory depression, hypoglycaemia) should be borne in mind, as labetalol crosses the placental barrier. Close monitoring 24-48 hours after birth is required. Beta-blockers may reduce uterine blood flow.
Labetalol should only be used during pregnancy if the benefits to the mother outweigh the potential risk for the foetus.
Lactation: Labetalol is excreted in breast milk in small amounts (approximately 0.004-0.07% of the maternal dose). No adverse effects have been reported so far. Caution should be exercised when labetalol is administered to breast feeding women.
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