Tranylcypromine - oral

Patient Medicine Information
Why do I need this medicine?
Tranylcypromine is used to treat depression.
How do I take this medicine?
Take Tranylcypromine exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take Tranylcypromine with or without food. Try to take it at the same time each day.

This medicine must be taken regularly for it to be effective. Continue to take this medicine even when you feel better. Do not stop taking it unless instructed otherwise, as stopping it suddenly could worsen your condition.
What should I do if I have forgotten to take this medicine?
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.
When should I not use this medicine?
Alert your doctor if you have the following:

- heart disease
- history of headaches
- history of liver disease
- pheochromocytoma (a tumour of the adrenal gland)
as Tranylcypromine may not be suitable for you.

Do not take Tranylcypromine if you are taking or have taken medicines for cough, mood disorder and heart disease. Please see the section “Can I take this with other medicines?” below for more information.
What should I take note of while taking this medicine?
Inform your doctor if you have:

- a history of epilepsy (seizures or fits)
- blood disorder
- diabetes
- history of drug and alcohol abuse

Let your doctor know if you are pregnant or breastfeeding.

For as long as you are taking Tranylcypromine, you may need to have regular blood tests to check your body's response to the medicine. Your doctor will advise you about how often you need to have blood tests.

If you are going for an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking Tranylcypromine.

What lifestyle changes should I make to cope with depression?

Regular exercise and eating a healthy diet will help increase energy and hormones in the body such as happy hormones that minimize mood swings. Get enough sleep, as lack of sleep may cause irritability, moodiness, sadness, and tiredness.
What side effects could I experience?
Tranylcypromine may cause drowsiness, dizziness and blurred vision. If affected, do not drive or take part in any activity in which you need to be alert.

This medicine may cause your blood pressure to fall suddenly when you get up from a sitting or lying down position and you may feel giddy. To minimise this problem, stand up slowly.

Other common side effects include any of the following: constipation, diarrhoea, nausea, stomach pain, changes in sexual drive, difficulty sleeping, rashes, headache, hair loss and dry mouth.

Tranylcypromine may cause a serious side effect affecting your blood pressure. If you have the following symptoms: headache that spreads to the front, irregular heartbeat, neck stiffness, nausea or vomiting, sweating that may be accompanied with fever, enlarged pupils and sensitivity to sunlight, alert your doctor immediately.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:

- tremors
- numbness or tingling sensation in the hands and feet
- unusual bleeding or bruising and frequent and persistent sore throat with fever
- changes in mood or behaviour (being too depressed, agitated, or having thoughts of self-harm)

Inform your doctor if any of these side effectsdo not go away or are severe, or if you experience other side effects.
Can I take this with other medicines?
Do not take Tranylcyclopromine with the following medicines:

- other monoamine oxidase inhibitors or MAOIs (medicines for depression) e.g. phenelzine
- dextromethorphan ( cough medicine)
- buspirone (medicine for sleep disorder)
- other medicines for depression e.g. fluoxetine, paroxetine, venlafexine, amitriptyline, imipramine
- carbamazepine (medicine for epilepsy)

Inform your doctor and pharmacist if you are taking any of these medicines:

- morphine (a painkiller)
- medicines used to treat diabetes e.g. tolbutamide, glipizide, insulin injections
- medicines used to control high blood pressure e.g. acebutolol, atenolol
- other medicines for sleep disorder e.g. amobarbital, pentobarbital
- levodopa (medicine to treat Parkinson's disease)

This list does not include all medicines that may interact with Tranylcypromine.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.
What special dietary instructions should I follow?
Avoid alcohol and high protein food that has been processed by aging, fermentation, pickling or smoking such as cheese, beer, wine, yeast spreads such as Marmite, or soya sauce. Also, avoid that are high in tyramine such as fava beans, broad bean pods, certain pickles such as sauerkraut. Do not consume excessive amounts of chocolate, tea and coffee. Ask your doctor about the types of food you should avoid.
How should I store this medicine?
Store in a cool, dry place, protected from light, and away from the reach of children.

Medicines must not be used past the expiry date.
This information is independently developed by MIMS based on tranylcypromine - oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2023 MIMS. All rights reserved. Powered by
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in