Trientine dihydrochloride


Concise Prescribing Info
Indications/Uses
Wilson's disease.
Dosage/Direction for Use
Adult : PO 0.75-1.25 g/day in 2-4 divided doses. Max: 2 g/day.
Dosage Details
Oral
Wilson's disease
Adult: 0.75-1.25 g daily in 2-4 divided doses. Max: 2 g daily.
Child: <12 yr: 500-750 mg daily in 2-4 divided doses. Max: 1.5 g daily.
Administration
Should be taken on an empty stomach. Take at least 1 hr before or 2 hr after meals, & at least 1 hr before or after any other medicine, food or milk.
Contraindications
Hypersensitivity.
Special Precautions
Monitor for signs of iron deficiency anaemia especially in children, menstruating or pregnant females. Take on an empty stomach, at least 1 hr before meals or 2 hr after meals and at least 1 hr apart from any other drug, food or milk to maximise drug absorption. Swallow whole with water and do not open or chew the capsule. Monitor temperature nightly during first month of treatment and patient should report any symptoms such as fever or skin eruption. Pregnancy.
Adverse Reactions
Iron deficiency, SLE, dystonia, muscular spasm, myasthenia gravis, nausea, skin rashes, duodenitis, colitis.
Drug Interactions
Iron containing preparations should not be taken within 2 hr of admin of trientine. Decreased absorption with mineral supplements and other drugs.
Action
Description: Trientine is a copper chelator used in the treatment of Wilson's disease to aid in the removal of copper ions. It is usually used in patients who are not tolerant of penicillamine.
Storage
Store at 2-8°C (36-46°F).
Disclaimer: This information is independently developed by MIMS based on Trientine dihydrochloride from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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