Trihexyphenidyl


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : PO Parkinsonism Initial: 1 mg/day, gradually increased at intervals of 3-5 days by increments of 2 mg until 6-10 mg/day in 3-4 divided doses. Postencephalitic patients: Up to 12-15 mg/day. Drug-induced extrapyramidal symptoms Initial: 1 mg/day, increased to 5-15 mg/day in 3-4 divided doses.
Dosage Details
Oral
Drug-induced extrapyramidal symptoms
Adult: Initially, 1 mg daily, increased to 5-15 mg daily in 3-4 divided doses.
Elderly: May require lower doses.

Oral
Parkinsonism
Adult: Initially, 1 mg daily, gradually increased at intervals of 3-5 days by increments of 2 mg until 6-10 mg daily in 3-4 divided doses. Postencephalitic patients: Up to 12-15 mg daily.
Elderly: May require lower doses.
Administration
Should be taken with food. Best taken w/ meals. Take before meals if dry mouth occurs, after meals if drooling/nausea occurs. Take at the same time each day.
Special Precautions
Patient w/ arteriosclerosis, history of drug idiosyncrasy. CV disease, glaucoma, GI obstruction, prostatic hyperplasia and/or urinary stricture. Not intended for treatment of tardive dyskinesia. Avoid abrupt withdrawal. Hepatic and renal impairment. Elderly. Pregnancy and lactation.
Adverse Reactions
Dryness of the mouth, nausea, constipation, vomiting, dizziness, drowsiness, headache, blurred vision, mydriasis, nervousness, tachycardia, urinary hesitancy or retention, increased intraocular tension, angle-closure glaucoma, weakness, rashes, dilatation of the colon, paralytic ileus, and suppurative parotitis. Rarely, psychiatric disturbances (e.g. delusion, amnesia, depersonalization, sense of unreality, paranoia).
Patient Counseling Information
May impair mental or physical abilities e.g. operating machinery or driving.
MonitoringParameters
Perform gonioscopic examination prior to initiation of therapy. Monitor intraocular pressure at regular intervals during prolonged treatment.
Overdosage
Symptoms: Flushing, dryness of the skin, dilated pupils, dry mouth and tongue, tachycardia, rapid respiration, hyperpyrexia, HTN, nausea, vomiting, rashes on face or upper trunk; restlessness, confusion, hallucinations, paranoid and psychotic reactions, incoordination, delirium and occasionally convulsions; CNS depression may occur w/ coma, circulatory and resp failure, death. Management: Symptomatic and supportive treatment. Maintain adequate airway. Admin diazepam to control excitement and convulsions but consider risk of CNS depression. Hypoxia and acidosis should be corrected.
Drug Interactions
Increased antimuscarinic side effects w/ phenothiazines, clozapine, antihistamines, disopyramide, nefopam and amantadine. Synergistic effect when concomitantly used w/ TCAs. Concurrent admin w/ MAOIs may cause dry mouth, blurred vision, urinary hesitancy or retention and constipation. May antagonise effect of metoclopramide and domperidone on GI function. Reduced absorption of levodopa. May antagonise effect of parasympathomimetics.
Food Interaction
Sedative effects may be potentiated w/ alcohol.
Action
Description: Trihexyphenidyl HCl is a tertiary amine antimuscarinic which exerts a direct inhibitory effect on the parasympathetic nervous system. It also exhibits a direct spasmolytic action on smooth muscle, weak mydriatic, antisialagogue and cardiovagal blocking effects.
Onset: W/in 1 hr.
Duration: 6-12 hr.
Pharmacokinetics:
Absorption: Rapidly and well absorbed from the GI tract. Time to peak plasma concentration: 1.3 hr.
Metabolism: Undergoes hydroxylation of the alicyclic group.
Excretion: Via urine (as unchanged drug) and bile. Elimination half-life: 33 hr.
Chemical Structure

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Storage
Store between 20-25°C.
Disclaimer: This information is independently developed by MIMS based on Trihexyphenidyl from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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