Hypersensitivity. Risk of anaphylaxis & angioedema. Discontinue use if serious dermatological reactions, seizure aggravation or significant bone marrow depression develops. Hyponatraemia; preexisting renal conditions associated w/ low Na or patients on Na-lowering co-medication; cardiac insufficiency & secondary heart failure; hypothyroidism. Suicidal ideation or behaviour. Initial testing for patients +ve on HLA-B* 1502 allele (eg, Chinese ancestry) & HLA-A* 3101. Monitor serum Na in case of fluid retention; thyroid function especially in childn ≤2 yr. Avoid abrupt discontinuation. Women taking hormonal contraceptives. Concomitant use w/ alcohol. May affect ability to drive or use machines. Renal impairment (CrCl <30 mL/min). Hepatitis & severe hepatic impairment. Women of childbearing potential should use highly effective contraception. Pregnancy. Not to be used during lactation.
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