Hypersensitivity. Risk of anaphylaxis & angioedema. Discontinue use if serious dermatological reactions or significant bone marrow depression develops. Seizure aggravation; hyponatraemia; preexisting renal conditions associated w/ low Na or patients on Na-lowering co-medication; cardiac insufficiency & secondary heart failure; hypothyroidism. Suicidal ideation or behaviour. Initial testing for patients +ve on HLA-B* 1502 allele (eg, Chinese ancestry). Monitor serum Na in case of fluid retention & thyroid function. Avoid abrupt discontinuation. Women taking hormonal contraceptives. Concomitant use w/ alcohol. May affect ability to drive or operate machines. Renal impairment (CrCl <30 mL/min). Hepatitis & severe hepatic impairment. Pregnancy. Not to be used during lactation. Childn <2 yr.
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