Trileptal

Trileptal

oxcarbazepine

Manufacturer:

Novartis

Distributor:

DKSH
Concise Prescribing Info
Contents
Oxcarbazepine
Indications/Uses
Epilepsy: Partial or generalized tonic-clonic seizures.
Dosage/Direction for Use
Adult & elderly 600-2,400 mg daily in 2 divided doses. Childn 8-10 mg/kg daily in 2 divided doses.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to oxcarbazepine or eslicarbazepine.
Special Precautions
Hypersensitivity. Risk of anaphylaxis & angioedema. Discontinue use if serious dermatological reactions or significant bone marrow depression develops. Seizure aggravation; hyponatraemia; preexisting renal conditions associated w/ low Na or patients on Na-lowering co-medication; cardiac insufficiency & secondary heart failure; hypothyroidism. Suicidal ideation or behaviour. Initial testing for patients +ve on HLA-B* 1502 allele (eg, Chinese ancestry). Monitor serum Na in case of fluid retention & thyroid function. Avoid abrupt discontinuation. Women taking hormonal contraceptives. Concomitant use w/ alcohol. May affect ability to drive or operate machines. Renal impairment (CrCl <30 mL/min). Hepatitis & severe hepatic impairment. Pregnancy. Not to be used during lactation. Childn <2 yr.
Adverse Reactions
Somnolence, headache, dizziness, diplopia, vomiting, nausea, fatigue. Increased wt, asymptomatic hyponatraemia, agitation, affect lability, confusional state, depression, apathy, ataxia, tremor, nystagmus, amnesia, attention & visual disturbance, blurred vision, vertigo, diarrhoea, abdominal pain, constipation, rash, alopecia, acne, asthenia. Childn 1 mth-4 yr: Ataxia, irritability, vomiting, lethargy, fatigue, nystagmus, tremor, decreased appetite, increased blood uric acid.
Drug Interactions
Felodipine, OCs, antiepileptics (eg, carbamazepine, phenobarb, phenytoin), immunosuppressants (eg, ciclosporin), rifampicin.
MIMS Class
ATC Classification
N03AF02 - oxcarbazepine ; Belongs to the class of carboxamide derivatives antiepileptic.
Presentation/Packing
Form
Trileptal FC tab 300 mg
Packing/Price
50's
Form
Trileptal FC tab 600 mg
Packing/Price
50's
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