Enhanced or prolonged resp depression w/ opioid premed, barbiturates, benzodiazepines, neuroleptics, general anaesth, other non-selective CNS depressants eg, alcohol; clonidine; Higher incidence of hypotension w/ droperidol. Decreased clearance w/ CYP3A4 inhibitors. Increased exposure &/or prolonged exposure w/ fluconazole or voriconazole. Bradycardia & possible cardiac arrest w/ non-vagolytic muscle relaxants eg, vecuronium. Increased risk of serotonin syndrome w/ serotonergic drugs eg, SSRI, SNRI, MAOI. Increased plasma conc of etomidate. Increased terminal plasma t½
& reduced plasma clearance of midazolam. Incompatibility w/ pentobarbital Na, methohexital Na, thiopental Na, nafcillin.