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Each mL of TRUSOPT 2% contains 20 mg dorzolamide (22.3 mg of dorzolamide hydrochloride).
TRUSOPT Sterile Ophthalmic Solution contains dorzolamide hydrochloride, which is described chemically as (4S-trans)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b] thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride.
Dorzolamide hydrochloride is optically active.
The specific rotation is 405α25° (C=1, water)=~-17°.
Its empirical formula is C10H16N2O4S3·HCl.
Dorzolamide hydrochloride has a molecular weight of 360.9 and a melting point of about 264°C. It is a white to off-white, free-flowing crystalline powder, which is soluble in water and slightly soluble in methanol and ethanol.
Excipients/Inactive Ingredients: TRUSOPT Ophthalmic Solution: hydroxyethyl cellulose, mannitol, sodium citrate dihydrate, sodium hydroxide (to adjust pH) and water for injection. Benzalkonium chloride 0.0075% is added as a preservative.
