Tuberculin Purified Protein Derivative

Generic Medicine Info
Indications and Dosage
Mantoux test
Adult: As a preparation containing 5 Tuberculin Units (TU)/0.1 ml: Inject slowly preferably on the palm-side-up surface of the forearm, 2-4 inches below the elbow, using a short (¼-½ inch) 26-27 gauge needle. A wheal of ≤6 mm should be seen, if not, the test should be repeated using another site at least 2 inches away from the original site. Measure the induration 48-72 hr after test admin. No reaction or an induration of <5 mm is considered negative; induration between 5-9 mm is considered a doubtful reaction; induration ≥10 mm is considered a positive reaction.
Special Precautions
Patients with a history of TB, suspected or having active TB. Reduced response in viral or severe bacterial infection, neoplastic disease especially lymphoma, sarcoidosis, live virus vaccine (e.g. measles, mumps, rubella), ultraviolet light treatment, chronic renal failure. Patients on corticosteroids or immunosuppressants, dehydrated or with poor nutrition. Do not inject IV, IM or SC. Do not massage or rub inj site. Avoid inj into hairy areas, areas near veins, muscle margin, sores or scars. Pregnancy.
Adverse Reactions
Pain, itch, discomfort at inj site. In very sensitive patients, vesiculation, ulceration or necrosis at test site may occur.
Potentially Fatal: Anaphylactic reactions.
Intradermal/Parenteral: C
Description: Tuberculin is a purified protein derivative (PPD) preparation obtained from the culture of Mycobacterium tuberculosis or M. bovis. It is used as a skin test to aid in the diagnosis of tuberculosis in individuals suspected of having clinical tuberculosis.
Onset: Delayed hypersensitivity reactions: 5-6 hr. Peak effect: 48-72 hr.
Duration: Reactions will subside over a few days.
Store between 2-8°C (35-48°F). Admin the skin test as soon as the syringe is filled as some of the tuberculin solution may adhere to the syringe surface.
MIMS Class
Vaccines, Antisera & Immunologicals
Disclaimer: This information is independently developed by MIMS based on Tuberculin Purified Protein Derivative from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by
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