Ubidecarenone


Generic Medicine Info
Indications and Dosage
Oral
Angina pectoris
Adult: 150-600 mg daily in divided doses.

Oral
Heart failure
Adult: 50-150 mg daily in 2-3 divided doses.
Administration
Should be taken with food.
Special Precautions
Avoid intense exercise during ubidecarenone therapy.
Adverse Reactions
Gastric discomfort, anorexia, diarrhoea, nausea, skin rash, heart burn. Increase in LFT with doses >300 mg/day.
Drug Interactions
Decreased serum levels with statins. Possible decrease in INR with warfarin.
Action
Description: Ubidecarenone (also known as ubiquinone or coenzyme Q10) is a naturally occurring coenzyme structurally similar to vitamin K. It is involved in electron transport and energy production in the mitochondria. Although found in all human cells, it is present in high concentrations in the heart, kidney, liver and pancreas. It is also found in dietary supplements and has been tried in conditions associated with coenzyme deficiency and also as an adjunct in CV disorders including mild or moderate heart failure.
Pharmacokinetics:
Absorption: Poor and slow GI absorption; absorption increased with high fat food.
Distribution: May undergo enterohepatic recycling. Plasma half life: 34 hr.
Metabolism: Extent of hepatic metabolism unknown.
Excretion: Mainly via bile, with >60% excreted unchanged in faeces.
Disclaimer: This information is independently developed by MIMS based on Ubidecarenone from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2021 MIMS. All rights reserved. Powered by MIMS.com
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