tegafur + uracil


TTY Biopharm


Concise Prescribing Info
Tegafur 100 mg, uracil 224 mg
Remission of subjective & objective symptoms in head & neck, gastric, colorectal, liver, gallbladder, bile duct, pancreatic, lung, breast, bladder, prostatic & uterine cervical cancers. Colorectal cancer in combination w/ folinate.
Dosage/Direction for Use
300-600 mg daily in 2-3 divided doses. Uterine cervical cancer Total dose: 600 mg daily in 2-3 doses. Doses may apply to combination regimen w/ other antineoplastics. Combination therapy w/ folinate for colorectal cancer Adult Tegafur 300-600 mg + folinate 75 mg daily in 3 divided doses. Repeat a course of 28-day consecutive administration, followed by 7-day rest period.
Should be taken on an empty stomach: Take at least 1 hr before or after meals.
Hypersensitivity. Concomitant therapy w/ sorivudine. Pregnancy & lactation.
Special Precautions
Bone marrow depression. Monitor hematologic, hepatic & renal function. Infectious diseases, varicella, gastric or duodenal symptoms, glucose intolerance, heart disease. Patients on or previously treated w/ chemotherapy. Hepatic & renal impairment. Childn. Elderly.
Adverse Reactions
Bone marrow depression, fulminant hepatitis, dehydration, severe enteritis, leukoencephalopathy, anosmia, interstitial pneumonia, silence angina.
Drug Interactions
Serious blood dyscrasia & GI disorder w/ tegafur, gimeracil & oteracil K. Enhanced warfarin K. Elevated blood conc w/ sorivudine. Intensified phenytoin action. Exaggerated adverse reactions w/ other antimalignant tumor agents or radiation therapy.
ATC Classification
L01BC53 - tegafur, combinations ; Belongs to the class of antimetabolites, pyrimidine analogues. Used in the treatment of cancer.
Ufur cap
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