Ufur

Ufur Adverse Reactions

tegafur + uracil

Manufacturer:

TTY Biopharm

Distributor:

Pharm-D
Full Prescribing Info
Adverse Reactions
(rarely: <0.1%, infrequently: 0.1%~<5%, no specific designation: frequency unknown).
Severe adverse reactions: Bone marrow depression such as pancytopenia or agranulocytosis. Pancytopenia or agranulocytosis may occur rarely. Anemia, leucopenia, thrombocytopenia, or bleeding tendency may occur infrequently. Accordingly, patients should be closely monitored by regular blood examinations (especially frequent in the early stage of administration). If abnormalities appear, take proper treatments such as discontinue administration.
Severe liver dysfunction: Severe liver dysfunction such as fulminant hepatitis may occur rarely. Accordingly, patients should be closely monitored by regular liver function test (especially frequent in the early stage of administration). If abnormalities appear, discontinue administration and take proper treatments.
Dehydration: If severe diarrhea occurs, discontinue administration and take proper treatments as fluid replacement.
Severe enteritis: Hemorrhagic enteritis, ischemic enteritis, or necrotic enteritis may occur. Accordingly, patients should be monitored closely. If severe abdominal pain or diarrhea occurs, discontinue administration and take proper treatments.
Leukoencephalopathy: Somnolence, consciousness disturbance, sensory disturbance, extrapyramidal symptoms, urinary incontinence, tetraplegia, speech disorder, gait disturbance, disturbed orientation, or hypomensia that leads to leukoencephalopathy may occur rarely. Precursors of such symptoms are dizziness/light headed feeling, numbness, impaired tongue movement, gait tripping, or forgetfulness. Patients should therefore be closely monitored. Discontinue administration if any such abnormalities appear.
Anosmia: Anosmia may occur rarely. Accordingly, patients should be monitored closely. If abnormalities appear, discontinue administration and take proper treatments.
Interstitial pneumonia: Interstitial pneumonia may occur rarely. Accordingly, patients should be monitored closely. Discontinue administration if abnormalities appear, and take proper treatments.
Silence angina: Silence angina may occur rarely. Accordingly, patients should be monitored closely. Discontinue administration if abnormalities appear, and take proper treatments.
Other adverse reactions: Liver: Jaundice and elevation of GOT or GPT may occur infrequently. Fatty liver may occur rarely. Accordingly, patients should be monitored closely. If abnormalities appear, take proper treatments such as discontinuation of administration.
Kidney: Proteinuria or hematuria may occur rarely. Increased BUN or creatinine may occur infrequently. Accordingly, patients should be monitored closely. If abnormalities appear, take proper treatments such as discontinuation of administration.
Gastro-intestine: Anorexia, nausea, vomiting, diarrhea, stomatitis, epigastric pain, abdominal pain, gastric/duodenal ulcers, heart burn, abdominal distension, taste abnormality, or gastritis may occur infrequently. Angular stomatitis, glossitis, borborygmus, dry mouth, constipation, difficult swallowing or gastrointestinal hemorrhage may occur rarely. Accordingly, patients should be monitored closely. If abnormalities appear, take proper treatments such as dose reduction or discontinuation of administration. Discontinue administration if ulcer or hemorrhage occurs.
Psychoneurologic system: Malaise or vertigo may occur infrequently. Headache, excitement or tinnitus may occur rarely.
Skin: Skin abnormalities may occur infrequently, such as pigmentation, keratosis, nail abnormality, blisters, erosion or dermatitis (which tend to develop on the palms or soles), as well as edema or alopecia. Flushing, SLE-like eruption, or photosensitive reactions may occur rarely. Accordingly, patients should be closely monitored. If abnormalities appear, take proper treatments such as discontinuation of administration.
Pancreas: Acute pancreatitis may occur rarely. Accordingly, patients should be monitored closely. If abdominal pain or an elevation of serum amylase and lipase appears, take proper treatments such as discontinuation of administration.
Hypersensitivity: Rash or itching may occur infrequently. Urticaria may occur rarely. Discontinue administration if abnormalities appear.
Cardiovascular: Distressed feeling of chest, chest pain, or abnormal ECG (ST elevation, etc.) may occur rarely.
Others: Fever may occur infrequently. Cough/sputum, arthralgia, glycosuria, burning sensation, bloody sputum, or conjunctival congestion may occur rarely.
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