Unasyn IM/IV

Unasyn IM/IV

ampicillin + sulbactam

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Per 750 mg powd for inj  Sulbactam Na 250 mg, ampicillin Na 500 mg. Per 1.5 g powd for inj Sulbactam Na 500 mg, ampicillin Na 1 g. Per 3 g powd for inj Sulbactam Na 1 g, ampicillin Na 2 g
Indications/Uses
Upper & lower resp tract infections including sinusitis, otitis media, epiglottitis, bacterial pneumonia, UTI, pyelonephritis; intra-abdominal infections including peritonitis, cholecystitis, endometritis, pelvic cellulitis; bacterial septicemia; skin, soft tissue, bone, joint & gonococcal infections. Peri-op prophylaxis for post-op sepsis reduction in abdominal/pelvic surgery & in termination of pregnancy/caesarean section.
Dosage/Direction for Use
Adult 1.5-12 g daily in divided doses every 6-8 hr. Max: Sulbactam 4 g daily. Less severe infections May be treated every 12 hr. Prophylaxis of surgical infections 1.5-3 g at anesth induction, may be repeated every 6-8 hr. Uncomplicated gonorrhoea 1.5 g as single dose w/ concomitant probenecid 1 g to prolong plasma conc of Unasyn. Childn, infant, neonate 150 mg/kg daily in divided doses every 6-8 hr. Neonate during 1st wk of life 75 mg/kg daily in divided doses every 12 hr.
Contraindications
Special Precautions
Discontinue use if serious & occasionally fatal hypersensitivity (anaphylactic) & severe skin reactions, superinfection occur. Not to be used in infectious mononucleosis. Overgrowth of nonsusceptible organism; Clostridium difficile-associated diarrhea. Periodically check for organ system dysfunction during prolonged therapy. Drug-induced hepatic injury. Pregnancy & lactation.
Adverse Reactions
Anaemia, thrombocytopenia, eosinophilia; phlebitis; diarrhoea; hyperbilirubinaemia; inj site pain; increased alanine & aspartate aminotransferase.
Drug Interactions
Increased incidence of rashes w/ allopurinol. Substantial mutual inactivation w/ aminoglycosides. Additive effects w/ anticoagulants. Interfered bactericidal effect w/ bacteriostatic drugs eg, chloramphenicol, erythromycin, sulfonamides, tetracyclines. Reduced effectiveness of estrogen-containing OCs. Decreased methotrexate clearance. Decreased renal tubular secretion by probenecid. False positive glycosuria test.
MIMS Class
ATC Classification
J01CR04 - sultamicillin ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Presentation/Packing
Form
Unasyn IM/IV 3 g powd for inj (vial)
Packing/Price
3 g x 1's
Form
Unasyn IM/IV 750 mg powd for inj (vial)
Packing/Price
0.75 g x 1's
Form
Unasyn IM/IV 1.5 g powd for inj (vial)
Packing/Price
1.5 g x 1's
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