Unasyn Oral

Unasyn Oral

sultamicillin

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Sultamicillin: Sulbactam Na, ampicillin Na
Indications/Uses
Upper resp tract infections including sinusitis, otitis media, tonsillitis; lower resp tract infections including bacterial pneumonia, bronchitis, UTI, pyelonephritis; skin, soft tissue & gonococcal infections. Oral follow-up therapy to Unasyn IM/IV.
Dosage/Direction for Use
Adult including elderly & childn ≥30 kg 375-750 mg bd. Uncomplicated gonorrhea 2.25 g as single dose w/ concomitant probenecid 1 g to prolong plasma conc of Unasyn. Childn <30 kg 25-50 mg/kg daily in 2 divided doses.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Discontinue use if serious & occasionally fatal hypersensitivity (anaphylactic) & severe skin reactions, superinfection occur. Not to be used in infectious mononucleosis. Overgrowth of nonsusceptible organism; Clostridium difficile-associated diarrhea. Periodically check for organ system dysfunction during prolonged therapy. Renal function in neonates. Glucose-galactose malabsorption. Drug-induced hepatic injury. Pregnancy. Not recommended during lactation. Tab: Galactose intolerance, Lapp lactase deficiency. Powd for oral susp: Fructose intolerance, sucrase-isomaltase insufficiency.
Adverse Reactions
Candida infection; headache; diarrhoea, vomiting, abdominal pain, nausea; rash, pruritus.
Drug Interactions
Increased incidence of rashes w/ allopurinol. Additive effects w/ anticoagulants. Interfered bactericidal effect w/ bacteriostatic drugs eg, chloramphenicol, erythromycin, sulfonamides, tetracyclines. Reduced effectiveness of estrogen-containing OCs. Decreased methotrexate clearance. Decreased renal tubular secretion by probenecid. False positive glycosuria test.
MIMS Class
Penicillins
ATC Classification
J01CR04 - sultamicillin ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Presentation/Packing
Form
Unasyn Oral FC tab 375 mg
Packing/Price
100's
Form
Unasyn Oral susp 250 mg/5 mL
Packing/Price
30 mL x 1's
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