Unimed Pamidronate

Unimed Pamidronate Adverse Reactions

pamidronic acid


Mylan Lab


Full Prescribing Info
Adverse Reactions
Usually mild to transient. The most common adverse reactions are asymptomatic hypocalcaemia and fever (an increase in body temperature 1-2°C) typically occurring within 1st 48 hrs of infusion. Fever usually resolves spontaneously and does not require treatment.
Infection: Very rare: Reactivation of Herpes simplex and Herpes zoster.
Blood: Common: Anaemia, thrombocytopenia, lymphocytopenia.
Very rare: Leukopenia.
Immune system: Uncommon: Allergic reactions including anaphylactoid reactions, bronchospasm/dyspnoea, Quincke's (angioneurotic) edema.
Very Rare: Anaphylactic shock.
Central Nervous System: Common: Symptomatic hypocalcaemia, headache, insomnia, somnolence.
Uncommon: Seizures, agitation, dizziness, lethargy.
Very Rare: Confusion, visual hallucinations.
Special Senses: Common: Conjunctivitis.
Very rare: Scleritis, episcleritis, xanthopsia.
Cardiovascular system: Common: Hypertension.
Uncommon: Hypotension.
Very Rare: Left ventricular failure (dyspnoea, pulmonary edema), congestive heart failure (edema) due to fluid overload.
Gastrointestinal tract: Common: Nausea, vomiting, anorexia, abdominal pain, diarrhoea, constipation, gastritis.
Uncommon: Dyspnoea.
Skin: Common: Rash.
Uncommon: Pruritis.
Musculoskeletal system: Common: Transient bone pain, arthralgia, myalgia and generalized pain.
Uncommon: Muscle cramps.
Renal system: Uncommon: Acute renal failure.
Rare: Focal segmental glomerulosclerosis including the collapsing variant, nephritic syndrome.
Very Rare: Deterioration of preexisting renal disease, haematuria.
General disorders and administration site conditions: Very common: Fever and influenza like symptoms sometimes accompanied by malaise, rigor, fatigue and flushes.
Common: Reactions at the infusion site (pain, redness, swelling, induration, phlebitis, thrombophlebitis).
Biochemical changes: Very common: Hypocalcaemia, hypophosphataemia.
Common: Hypokalemia, hypomagnesaemia, increase in serum creatinine.
Uncommon: Abnormal liver function tests, increase in serum urea.
Very Rare: Hyperkalemia, hypernatremia.
Many of these undesirable effects may have been related to the underlying disease.
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