Cephalexin decreases the efficacy of oestrogen containing oral contraceptives. The concomitant use of probenecid will reduce the excretion of cephalexin; nephrotoxic drug such as aminoglycoside antibiotic-gentamicin may increase the risk of kidney damage with cephalexin. Concomitant use with loop diuretic-frusemide may enhance nephrotoxicity.
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