Urief

Urief

silodosin

Manufacturer:

Eisai

Distributor:

DKSH
Concise Prescribing Info
Contents
Silodosin
Indications/Uses
Bladder outlet obstruction associated w/ BPH in patients ≥50 yr.
Dosage/Direction for Use
Adult 4 mg bd. Hepatic impairment Start treatment at 2 mg/dose.
Administration
Should be taken with food: Take after breakfast & evening meal.
Contraindications
Special Precautions
Orthostatic hypotension. Retrograde ejaculation. Intraoperative floppy iris syndrome. Concomitant use w/ PDE-5 inhibitors, α1-blockers & other hypotensive drugs. Discontinue treatment if a decrease in BP occurs. May affect ability to drive & use machines. Hepatic & renal impairment. Male fertility. Elderly.
Adverse Reactions
Abnormal ejaculation; thirst, diarrhea, loose stools; dizziness; nasal congestion; lightheaded feeling, headache. Increased triglycerides, CRP, ALT, AST & γ-GTP.
Drug Interactions
Blocked metabolism w/ potent CYP3A4 inhibitors. Diminished ability to regulate BP on standing w/ hypotensive agents. Elevated plasma conc w/ azole antifungals eg, itraconazole. Enhanced hypotensive effect w/ PDE-5 inhibitors eg, sildenafil citrate, vardenafil HCl hydrate.
ATC Classification
G04CA04 - silodosin ; Belongs to the class of alpha-adrenoreceptor antagonists. Used in the treatment of benign prostatic hypertrophy.
Presentation/Packing
Form
Urief FC tab 4 mg
Packing/Price
3 × 10's
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