Concurrent administration of vancomycin and anaesthetic agents has been associated with erythema, histamine like flushing and anaphylactoid reactions.
Concurrent administration with other neurotoxic or nephrotoxic drugs, e.g. amphotericin B, streptomycin, neomycin, gentamicin, kanamycin, amikacin, tobramycin, viomycin, bacitracin, polymyxin B, colistin and cisplatin requires careful monitoring.
Diuretics such as ethacrynic acid and frusemide may aggravate ototoxicity.
Cholestyramine has been shown to bind vancomycin in-vitro.