If tuberculin testing has to be done it should be carried out before or simultaneously with vaccination since it has been reported that live viral vaccines may cause a temporary depression of tuberculin skin sensitivity. As this anergy may last up to a maximum of 6 weeks, tuberculin testing should not be performed within that period after vaccination to avoid false negative results.
In subjects who have received immune globulins or a blood transfusion, immunisation should be delayed for at least three months because of the likelihood of vaccine failure due to passively acquired varicella antibodies.
Salicylates should be avoided for 6 weeks after varicella vaccination as Reye's Syndrome has been reported following the use of salicylates during natural varicella infection.
Healthy subjects: Varilrix can be administered at the same time as any other vaccines. Different injectable vaccines should always be administered at different injection sites.
Inactivated vaccines can be administered in any temporal relationship to Varilrix.
Should a measles containing vaccine not be given at the same time as Varilrix, it is recommended that an interval of at least one month should be respected since it is recognised that measles vaccination may lead to short lived suppression of the cell mediated immune response.
High-risk patients: Varilrix should not be administered at the same time as other live attenuated vaccines.
Inactivated vaccines may be administered in any temporal relationship to Varilrix, given that no specific contraindication has been established. Different injectable vaccines should always be administered at different injection sites.