Vasopressin


Concise Prescribing Info
Indications/Uses
Listed in Dosage.
Dosage/Direction for Use
Adult : IV Initial control of variceal bleeding As argipressin: 20 u. IM/SC Cranial diabetes insipidus As argipressin: 5-20 u 4 hrly.
Dosage Details
Intravenous
Initial control of variceal bleeding
Adult: As argipressin: 20 units in 100 ml of glucose 5% infused over 15 min.

Parenteral
Cranial diabetes insipidus
Adult: As argipressin: 5-20 units SC/IM every 4 hr.
Contraindications
Hypersensitivity. Vascular disease especially coronary artery disease; chronic nephritis (until reasonable blood-nitrogen conc attained).
Special Precautions
Heart failure; migraine; epilepsy; asthma or other conditions which might be exacerbated by fluid retention; renal impairment; hypertension or other conditions that may worse with BP increase. Adjust fluid intake to avoid fluid overload. Lactation, pregnancy (especially 3rd trimester as it may have oxytocic effect).
Adverse Reactions
Pallor, vomiting, nausea, belching, abdominal cramps, tremour, pounding headache, vertigo, fluid retention, hyponatraemia, hypersensitivity reaction, sweating, urticaria, gangrene, desire to defecate, arrhythmias, bradycardia, angina, MI and bronchoconstriction.
Potentially Fatal: Anaphylaxis; cardiac arrest or shock.
IM/IV/Parenteral/SC: C
Drug Interactions
Carbamazepine, chlorpropamide, clofibrate, urea, fludrocortisone and tricyclic antidepressants may potentiate the antidiuretic action of vasopressin. Demeclocycline, noradrenaline, lithium, heparin and alcohol may decrease antidiuretic action of vasopressin. Ganglionic blockers may increase sensitivity to the pressor effect of vasopressin. Increased risk of QT prolongation with dolasetron.
Action
Description: Vasopressin is a posterior pituitary hormone which may be synthetically prepared or extracted from animals. It exerts direct antidiuretic action on the kidneys by increasing tubular reabsorption of water. Vasopressin also acts by constricting the peripheral blood vessels and causes the smooth muscle of the intestine, gall bladder and urinary bladder to contract. Vasopressin is given parenterally or intranasally in the form of argipressin or lypressin. Argipressin is a synthetic type of vasopressin derived from most mammals (including man but excluding pig) while lypressin is vasopressin from pig.
Storage
Store between 15-25°C (59-77°F).
Disclaimer: This information is independently developed by MIMS based on Vasopressin from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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