QTc prolongation due to increased plasma conc of astemizole, cisapride, pimozide, quinidine, terfenadine, ivabradine. Decreased plasma conc by carbamazepine, long-acting barbiturates. Decreased Cmax
& AUC w/ efavirenz, rifampicin, ritonavir, letermovir. Increased plasma conc of ergot alkaloids, lurasidone, naloxegol, tolvaptan, venetoclax, coumarins, ivacaftor, midazolam, other benzodiazepines, everolimus, ciclosporin, tacrolimus, long-acting opiates, methadone, NSAIDs, omeprazole, other proton-pump inhibitors, OCs, alfentanil, fentanyl, statins, sulphonylureas, vinca alkaloids, prednisolone. Decreased AUC w/ St. John's wort. Increased Cmax
& AUC w/ fluconazole, cimetidine. Increased/decreased Cmax
& AUC w/ rifabutin, phenytoin. Inhibited metabolism of HIV PIs, NNRTIs.