Discontinue use & not to be re-administered in patients w/ history of angioedema. Not to be used in primary hyperaldosteronism. Not recommended in dual blockade of renin-angiotensin-aldosterone system. Risk of hypotension in Na &/or vol-depleted patients; bilateral renal artery stenosis or stenosis to solitary kidney; aortic or mitral stenosis, hypertrophic obstructive cardiomyopathy; severe CHF. Regularly monitor K levels, renal function, electrolytes & BP. Galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption. Not recommended in concomitant use w/ K supplements, K-sparing diuretics, K-containing salt substitutes or other agents increasing K levels eg, heparin. Kidney transplantation; severe renal impairment (CrCl <10 mL/min), patients undergoing dialysis. Mild to moderate hepatic impairment w/o cholestasis. Not to be used during 2nd & 3rd trimesters of pregnancy. Not recommended during lactation. Childn & adolescents <18 yr.