The effects of the medicines or groups of substances as follows may be affected by concomitant treatment with acetylsalicylic acid.
Enhanced effects ranging up to an increased risk of side effects: Anticoagulants (e.g. coumarin, heparin) and thrombolytic drugs: acetylsalicylic acid can increase the risk of bleeding if taken before anticoagulant treatment.
Other platelet aggregation inhibitors (drugs that inhibit the clumping together of blood platelets), e.g. ticlopidine, Clopidogrel: increased bleeding risk.
Drug product containing cortisone or cortisone-like substances (with the exception of products that are applied topically or cortisone replacement therapy for Addison's disease): increased risk for gastrointestinal side effects.
Alcohol: increased risk of gastrointestinal ulcers and bleeding.
Other analgesics and anti-inflammatory medicines (nonsteroidal anti - inflammatory drugs) and other antirheumatic medicines in general: increased risk for gastrointestinal ulcers and bleeding.
Antidiabetics: the blood glucose level can be reduced.
Digoxin (a drug to strengthen the heart muscle contraction).
Methotrexate (a drug used to treat cancer and certain rheumatic disorders).
Valproic acid (a drug used to treat convulsions of the brain).
Selective Serotonin Re-uptake inhibitors (certain medicines for treatment of depression): increased risk for gastrointestinal bleeding.
Certain antibiotics (sulphonamides and sulphonamide combinations, e.g. sulphamethoxazole/ trimethoprim).
Triiodothyronine (a medicine for treating hypothyroidism).
Weakening of effects: Certain medicines that increase the excretion of urine (diuretics so-called aldosterone antagonists, e.g. spironolactone and canrenoate, and loop diuretics, e.g. furosemide).
Certain antihypertension drugs (in particular angiotensin converting enzyme inhibitors).
Gout remedies that promote the excretion of uric acid (e.g. probenecid, benzbromarone).