Concise Prescribing Info
Contents
Cefuroxime axetil
Indications/Uses
Upper resp tract infections eg, otitis media, sinusitis, tonsillitis & pharyngitis, lower resp tract infections eg, pneumonia, acute bronchitis & acute exacerbations of chronic bronchitis, GUT infections eg, pyelonephritis, cystitis & urethritis, skin & soft-tissue infections eg, furunculosis, pyoderma & impetigo, gonorrhea, acute uncomplicated gonococcal urethritis & cervicitis.
Dosage/Direction for Use
Adult Most infections 250 mg bd. UTI 125 mg bd. Mild to moderate lower tract infections eg, bronchitis 250 mg bd. More severe lower tract infections or if pneumonia is suspected 500 mg bd. Pyelonephritis 250 mg bd. Uncomplicated gonorrhoea 1 g as single dose. Sequential therapy: Pneumonia Cefuroxime Na 1.5 g inj tds or bd (IV or IM) for 48-72 hr followed by cefuroxime axetil oral therapy 500 mg bd for 7-10 days. Acute exacerbations of chronic bronchitis Cefuroxime Na 750 mg tds or bd (IV or IM) for 48-72 hr followed by cefuroxime axetil oral therapy 500 mg bd for 5-10 days. Childn Most infections 125 mg bd, max dose: 250 mg daily. Childn ≥2 yr Otitis media or more severe infections 250 mg bd, max dose: 500 mg daily.
Administration
Should be taken with food.
Contraindications
Hypersensitivity to cephalosporins.
Special Precautions
Penicillin-sensitive patients. History of GI disease, particularly colitis. Prolonged use. Transient or persistent renal insufficiency. Pregnancy & lactation. Childn <3 mth.
Adverse Reactions
GI disturbances, pseudomembranous colitis, headache, eosinophilia, transient increases of hepatic enzyme levels.
Drug Interactions
Diuretics eg, frusemide.
MIMS Class
ATC Classification
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Xylid tab 250 mg
Packing/Price
10's;50's
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