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Xyntha

Xyntha

factor viii

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Plasma/albumin-free recombinant coagulation factor VIII
Indications/Uses
Control & prevention of bleeding episodes & for routine & surgical prophylaxis in patients w/ hemophilia A (congenital factor VIII deficiency/classic hemophilia). Xyntha does not contain von Willebrand factor & therefore is not indicated in patients w/ von Willebrand's disease.
Dosage/Direction for Use
Individualised dosage. Early hemarthrosis, minor muscle/oral bleeds 20-40 IU/dL 12-24 hrly for at least 1 day. Bleeding into muscles/oral cavity, mild head trauma 30-60 IU/dL 12-24 hrly for 3-4 days. GI, intracranial, intra-abdominal or intrathoracic bleeding, fractures 60-100 IU/dL 8-24 hrly. Minor surgery 30-60 IU/dL 12-24 hrly for 3-4 days. Tooth extraction 30-60 IU/dL single infusion + oral antifibrinolytic therapy w/in 1 hr. Major surgery 60-100 IU/dL 8-24 hrly. Routine Prophylaxis Adult & adolescents ≥12 yr 30 IU/kg 3x wkly. Childn <12 yr Initially, 25 IU/kg every other day.
Contraindications
Hypersensitivity to coagulation factor VIII or hamster proteins.
Special Precautions
Discontinue use if hypersensitivity reactions occur. Monitor for development of factor VIII inhibitors. Pregnancy & lactation. Elderly ≥65 yr.
Adverse Reactions
Headache, arthralgia, pyrexia, cough. Diarrhea, vomiting, asthenia.
MIMS Class
Haemostatics
ATC Classification
B02BD02 - coagulation factor VIII ; Belongs to the class of blood coagulation factors. Used in the treatment of hemorrhage.
Presentation/Packing
Form
Xyntha powd for inj (vial) 1000 IU
Packing/Price
1's
Form
Xyntha powd for inj (vial) 2000 IU
Packing/Price
1's
Form
Xyntha powd for inj (vial) 250 IU
Packing/Price
1's
Form
Xyntha powd for inj (vial) 500 IU
Packing/Price
1's
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