Pharmacology: Pharmacodynamics: Ibuprofen inhibits the enzyme cyclo-oxygenase, resulting in decreased formation of precursor of prostaglandins and thromboxanes from arachidonic acid. Although many of the therapeutic (and adverse) effects of these medications may result from inhibition of prostaglandin synthesis in various tissue, other actions may also contribute significantly to their therapeutic effects. In clinical studies in patients with rheumatoid arthritis and osteoarthritis, Ibuprofen has been shown to be comparable to Aspirin in controlling pain and inflammation and with a statistically significant reduction in the milder gastrointestinal side effects.
Pharmacokinetics: Ibuprofen is rapidly absorbed when administered orally. Peak serum Ibuprofen levels are generally attained one to two hours after administration. Ibuprofen is rapidly metabolized and eliminated in the urine. The excretion is virtually complete 24 hours after the last dose. The serum half-life is 1.8 to 2.0 hours.