Cimetidine, praziquantel and dexamethasone have been reported to increase the plasma levels of the albendazole active metabolite.
Grapefruit juice may increase the bioavailability of albendazole but less than the increase observed after a fatty meal.
Phenytoin, carbamazepine, and phenobarbital appear to induce the oxidative metabolism of albendazole, resulting in significantly reduced concentrations of albendazole sulfoxide. This interaction is likely to be clinically significant when albendazole is used to treat systemic worm infections. The interaction is probably not clinically significant when albendazole is used for intestinal worm infections.
Chinese Ginseng may theoretically reduce the intestinal concentration of albendazole active metabolite.
Albendazole may theoretically inhibit theophylline metabolism and increase toxicity.