Zerbaxa Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Storage Patient Counseling Information MIMS Class ATC Classification Presentation/Packing

Concise Prescribing Info

Contents

Ceftolozane 1 g, tazobactam 500 mg

Indications/Uses

Infections caused by susceptible microorganisms in complicated intra-abdominal infections in combination w/ metronidazole & complicated UTI, including pyelonephritis.

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Dosage/Direction for Use

Adult ≥18 yr Complicated intra-abdominal infections 1.5 g every 8 hr for 4-14 days in conjunction w/ metronidazole 500 mg IV every 8 hr. Complicated UTI 1.5 g every 8 hr for 7 days. CrCl 30-50 mL/min 750 mg IV every 8 hr, 15-29 mL/min 375 mg IV every 8 hr. ESRD on hemodialysis Single loading dose: 750 mg followed by maintenance dose: 150 mg every 8 hr for the remainder of treatment period.

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Overdosage

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Contraindications

Hypersensitivity to ceftolozane, tazobactam, other cephalosporins. Severe hypersensitivity (eg, anaphylactic & severe skin reaction) to other β-lactam antibacterial agents (eg, penicillins or carbapenems).

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Special Precautions

Not for direct inj. Cross-sensitivity to other cephalosporins, penicillins or other β-lactams. Clostridium difficile-associated diarrhea (CDAD). Risk of development of drug-resistant bacteria. Renal impairment. Pregnancy & lactation. Elderly ≥65 yr.

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Use In Pregnancy & Lactation

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Adverse Reactions

Nausea, diarrhea, headache, pyrexia, insomnia, vomiting, hyperkalemia. Hypersensitivity, CDAD.

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Drug Interactions

Prolonged tazobactam t_½by probenecid.

Storage

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Description

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Action

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MIMS Class

Cephalosporins

ATC Classification

J01DI54 - ceftolozane and beta-lactamase inhibitor ; Belongs to the class of other cephalosporins and penems. Used in the systemic treatment of infections.

Patient Counseling Information

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Presentation/Packing

Form

Zerbaxa powd for inj (single-dose vial)

Packing/Price

(1.5 g) 10 × 1's

Zerbaxa

Manufacturer:

Merck Sharp & Dohme

Distributor:

Zuellig Pharma