Zinnat

Zinnat

cefuroxime

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Cefuroxime axetil
Indications/Uses
Upper & lower resp tract infections, GUT, skin & soft tissue infections, gonorrhoea, acute uncomplicated gonococcal urethritis & cervicitis.
Dosage/Direction for Use
Usual course of therapy: 7 days (5-10 days). Adult Most infections, UTI, pyelonephritis, mild to moderate lower resp tract infections eg, bronchitis 250 mg bd. More severe lower resp tract infections or if pneumonia is suspected 500 mg bd. Uncomplicated gonorrhoea 1 g as single dose. Tab Pneumonia Cefuroxime Na 1.5 g bd IV or IM for 48-72 hr, followed by oral cefuroxime axetil 500 mg bd for 7-10 days. Acute exacerbations of chronic bronchitis Cefuroxime Na 750 mg tds IV or IM for 48-72 hr, followed by oral cefuroxime axetil 500 mg bd for 5-10 days. Childn Most infections 125 mg bd. Otitis media or more severe infections 250 mg bd. Oral susp Childn 3 mth-12 yr Most infections 10 mg/kg bd. Max: 250 mg daily. Otitis media or more severe infections 15 mg/kg bd. Max: 500 mg daily.
Administration
Should be taken with food: Take immediately after meals for optimum absorption. Tab: Swallow whole, do not crush/split.
Contraindications
Hypersensitivity to cephalosporins.
Special Precautions
Allergic reaction to penicillins or other β-lactams. Overgrowth of non-susceptible organisms eg, enterococci & Clostridium difficile. Pseudomembranous colitis. May affect ability to drive & use machines. Pregnancy & lactation. Oral susp: Diabetic patients; phenylketonuria.
Adverse Reactions
Overgrowth of Candida; eosinophilia; headache, dizziness; GI disturbances eg, diarrhoea, nausea, abdominal pain; transient increase in ALT (SGPT), AST (SGOT), LDH.
Drug Interactions
Lowered bioavailability w/ drugs known to reduce gastric acidity. Lowered oestrogen reabsorption & reduced efficacy of combined OCs. False -ve result in ferricyanide test.
MIMS Class
ATC Classification
J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.
Presentation/Packing
Form
Zinnat oral susp 250 mg/5 mL
Packing/Price
(Tutti-frutti flavour) 100 mL x 1's; (Tutti-frutti flavour) 50 mL x 1's
/malaysia/image/info/zinnat oral susp 250 mg-5 ml/250 mg-5 ml x 50 ml?id=150cfb23-e944-4448-9e70-a7f500ecf022
/malaysia/image/info/zinnat oral susp 250 mg-5 ml/250 mg-5 ml x 100 ml?id=6a2595a8-532b-440b-9b9b-a5fb00dde72b
Form
Zinnat FC tab 250 mg
Packing/Price
10's;50's
Form
Zinnat oral susp 125 mg/5 mL
Packing/Price
(Tutti-frutti flavour) 50 mL x 1's
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