Zuellig Pharma
Concise Prescribing Info
Sertraline HCl
Symptomatic treatment of depression including depression accompanied by symptoms of anxiety in patients w/ or w/o history of mania. Obsessive compulsive disorders (OCD). Panic disorder w/ or w/o agoraphobia. Post-traumatic stress disorder (PTSD). Social phobia (social anxiety disorder).
Dosage/Direction for Use
Depression, OCD 50 mg daily. Panic disorder, PTSD & social phobia Initially 25 mg daily, increase dose to 50 mg daily after 1 wk. All dose changes should be made at intervals of ≥1 wk, max: 200 mg daily.
May be taken with or without food.
Hypersensitivity. MAOIs, pimozide.
Special Precautions
Monitor for emergence of signs & symptoms of serotonin syndrome or neuroleptic malignant syndrome, suicide/suicidal thoughts or clinical worsening, or glycemic control in diabetic patients. Risk factors for QTc prolongation or angle-closure glaucoma or history of glaucoma. Activation of mania/hypomania. Seizures; hyponatremia; bone fractures. Switching from antidepressants. False positive test results. Not to be used in combination w/ MAOI w/in 14 days of discontinuation. Avoid use w/ other drugs enhancing effects of serotonergic neurotransmission. Co-administration w/ SSRIs, drugs affecting platelet function. May affect ability to drive & use machines. Hepatic impairment. Women of childbearing potential must use effective contraception. Pregnancy & lactation. Childn & adolescents (long-term use).
Adverse Reactions
Nausea, diarrhoea/loose stools, anorexia, dizziness, somnolence, insomnia, dyspepsia; male sexual dysfunction (ejaculatory delay), tremor, dry mouth, increased sweating.
Drug Interactions
Increased pimozide levels. Increased risk of QTc prolongation &/or ventricular arrythmia w/ drugs prolonging QTc intevals. Increased in tremor w/ lithium. Reduced plasma levels w/ phenytoin. Monitor prothrombin time w/ warfarin. Changes in pharmacokinetic parameters w/ diazepam, tolbutamide. Decreased clearance w/ cimetidine. Concomitant use w/ sumatriptan. Not recommended in concomitant use w/ alcohol.
MIMS Class
ATC Classification
N06AB06 - sertraline ; Belongs to the class of selective serotonin reuptake inhibitors. Used in the management of depression.
Zoloft FC tab 50 mg
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