Monitor for emergence of signs & symptoms of serotonin syndrome or NMS, suicide/suicidal thoughts or clinical worsening, or glycemic control in diabetic patients. Risk factors for QTc prolongation or angle-closure glaucoma or history of glaucoma. Activation of mania/hypomania. Seizures; hyponatremia; bone fractures. Switching from antidepressants. False +ve test results. Not to be used in combination w/ MAOI w/in 14 days of discontinuation. Avoid use w/ other drugs enhancing effects of serotonergic neurotransmission. Co-administration w/ SSRIs, drugs affecting platelet function. May affect ability to drive & use machines. Hepatic impairment. Women of childbearing potential must use effective contraception. Pregnancy & lactation. Childn & adolescents (long-term use).