Zopam Injection

Zopam Injection

diazepam

Manufacturer:

SM Pharmaceuticals

Distributor:

SM Pharmaceuticals
Concise Prescribing Info
Contents
Diazepam
Indications/Uses
Motor excitation of diverse etiology & paranoid-hallucinatory states. Status epilepticus; tetanus. Relief of severe spasm of central, peripheral, rheumatic or tetanic origin.
Dosage/Direction for Use
Adult States of excitation 10-20 mg IM/IV tds. Status epilepticus Initially 10-20 mg IV, followed by 20 mg IM or IV drip infusion. Muscular spasm 10 mg IV once or bd. Tetanus 10 mg IV for 8 hr. Elderly Antianxiety, sedative-hypnotic, amnestic, anticonvulsant or adjunct skeletal muscle relaxant Initially 2-5 mg IM/IV per dose, may be increased gradually as needed. Childn 2-5 yr Status epilepticus & severe recurrent convulsive seizures 200-500 mcg slow IV every 2-5 min, may be repeated in 2-4 hr as needed. Max: 5 mg. Tetanus 1-2 mg IM/IV every 3 or 4 hr as needed. Childn ≥5 yr Status epilepticus & severe recurrent convulsive seizures 1 mg slow IV every 2-5 min, may be repeated in 2-4 hr as needed. Max: 10 mg. Tetanus 5-10 mg IM/IV every 3 or 4 hr as needed.
Contraindications
Hypersensitivity. Acute narrow & open angle glaucoma. Childn <2 yr.
Special Precautions
Hypersensitivity. Limited pulmonary reserve or unstable CV status. Circulatory insufficiency & myasthenia gravis; chronic resp insufficiency. History of alcohol or drug abuse. Psychiatric & paradoxical reactions. Anaphylaxis & angioedema. Complex sleep behaviours. Perioral endoscopic procedures. Concurrent use w/ narcotics, barbiturates or alcohol; opioids. May affect ability to drive or operate machinery. Renal or hepatic dysfunction. Avoid use during 1st trimester of pregnancy. Lactation. Not to be used in neonates. Childn <2 yr. Elderly & debilitated patients.
Adverse Reactions
Ataxia, dizziness or lightheadedness, drowsiness.
Drug Interactions
Increased CNS depressant effects w/ alcohol or other CNS depression-producing medications. Delayed absorption w/ antacids. Enhanced metabolism w/ antiepilepics eg, carbamazepine, phenobarb & phenytoin. Delayed elimination & increased plasma conc w/ cimetidine, estrogen-containing OCs, disulfiram or erythromycin. Potentiated hypotensive response w/ mecamylamine or trimethaphan. Increased plasma conc w/ INH. Prolonged t½ of ketamine. Decreased therapeutic effects of l-dopa. Prolonged elimination w/ omeprazole. Enhanced elimination w/ rifampin. Displacement from plasma-protein binding sites w/ Na valproate. Counteracted sedative & psychomotor effects w/ theophylline. Increased risk of resp depression, profound sedation, coma & death w/ opioids, clozapine, fentanyl derivatives.
MIMS Class
Anxiolytics
ATC Classification
N05BA01 - diazepam ; Belongs to the class of benzodiazepine derivatives anxiolytics. Used in the management of anxiety, agitation or tension.
Presentation/Packing
Form
Zopam inj 10 mg/2 mL
Packing/Price
2 mL x 10 × 1's
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