Usual adult and adolescent dose: Intra-muscular or intravenous, 100 to 500 mg (base); may be repeated every two to six hours, depending upon patient condition and response.
Note: Initial intravenous dosage should be administered over a period of thirty seconds (100-mg dose) to ten minutes (doses of 500 mg or higher).
Maintenance dosage (if required) should be no less than 25 mg per day.
Anaphylactic shock: May be a useful adjunct to adrenaline in severely affected patients; may be given intravenously in a dose equivalent to 100 to 300 mg of hydrocortisone.
Usual paediatric dose: Adreno-cortical insufficiency: Intra-muscular or intravenous, 186 to 280 mcg (0.186 to 0.28 mg) (base) per kg of body weight or 10 to 12 mg (base) per m2 of body surface a day in three divided doses.
Other indications: Intra-muscular, 666 mcg (0.666 mg) to 4 mg (base) per kg of body weight or 20 to 120 mg (base) per m2 of body surface every twelve to twenty-four hours.