Pregnancy: Corticosteroids cross the placenta. Although adequate studies have not been done in humans, there is some evidence that pharmacologic doses of corticosteroids may increase the risk of placental insufficiency, decreased birth weight, or stillbirth. However, teratogenic effects in humans have not been confirmed. Infants born to mothers who have received substantial doses of corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism and replacement therapy administered if required.
Breast-feeding: Problems in humans have not been documented. Breast-feeding is not recommended because it is excreted in breast milk and may cause unwanted effects, such as growth suppression and inhibition of endogenous steroid production, in the infant.
Fertility: Corticosteroids have been reported to increase or decrease the number or motility of spermatozoa but it is not known whether reproductive capacity in humans is adversely affected.