cetirizine + pseudoephedrine




Zuellig Pharma
Concise Prescribing Info
Cetirizine diHCl 5 mg, pseudoephedrine HCl 120 mg
Symptomatic treatment of acute rhinitis w/ nasal congestion, hypersecretion, nose &/or eye itching & watery eyes.
Dosage/Direction for Use
Adult & childn ≥12 yr 1 tab bd (morning & evening). Max: 2-3 wk. Moderate renal & hepatic impairment 1 tab daily.
May be taken with or without food: Swallow whole w/ some liqd, do not break/chew/crush.
Hypersensitivity to cetirizine, pseudoephedrine, ephedrine or any other piperazine. Severe HTN, ischaemic heart disease or arrhythmias, uncontrolled hyperthyroidism, phaeochromocytoma, elevated IOP, urinary retention, glaucoma; history of stroke, high risk of haemorrhagic stroke. Concomitant administration of dihydroergotamine. Patients receiving MAOI (up to 2 wk after discontinuation). Severe renal insufficiency. Childn <12 yr.
Special Precautions
Discontinue use if posterior reversible encephalopathy/reversible cerebral vasoconstriction syndrome, sudden loss of vision or decreased visual acuity eg, scotoma; abdominal pain, rectal bleeding or other symptoms of ischaemic colitis occur. DM, hyperthyroidism, arterial HTN, tachycardia, cardiac arrhythmia, ischaemic heart disease. Patients w/ predisposing factors of urinary retention eg, spinal cord lesion, prostatic hyperplasia or hypertrophy, bladder outflow obstruction; at risk for hypercoagulability eg, inflammatory bowel disease. Concomitant use w/ sympathomimetics including decongestants, anorexigenic substances or psychostimulants, TCAs, antihypertensives, alcohol & other CNS depressants, cardiac glycosides eg, digoxin or digitoxin; NSAIDs. Not to be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive or operate machinery. Moderate renal or hepatic impairment. Not to be used during pregnancy & lactation. Elderly.
Adverse Reactions
Nervousness, insomnia; vertigo, dizziness, headache, somnolence; tachycardia; dry mouth, nausea; asthenia.
Drug Interactions
Increased exposure of ritonavir. Hypertensive crisis w/ MAOIs. Increased arterial pressure w/ linezolid. Reduced antihypertensive effects of β-adrenergic blockers, methyldopa, guanethidine & reserpine. Increased absorption by antacids & PPIs. Reduced absorption by kaolin. Increased ectopic pacemaker activity w/ digoxin or digitoxin. May provoke or worsen ventricular arrhythmia w/ halogenated anaesth agents. Increased BP w/ other vasoconstrictors eg, bromocriptine, pergolide, lisuride, cabergoline, ergotamine, phenylpropanolamine, phenylephrine, ephedrine or NSAIDs. Interfered w/ allergy tests. Reduced & delayed peak plasma conc by high fat meal.
MIMS Class
Cough & Cold Preparations / Antihistamines & Antiallergics
ATC Classification
R01BA52 - pseudoephedrine, combinations ; Belongs to the class of systemic sympathomimetic preparations used as nasal decongestants.
Zyrtec-D tab
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in