Zyrtec-D

Zyrtec-D

cetirizine + pseudoephedrine

Manufacturer:

GlaxoSmithKline

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Cetirizine diHCl 5 mg, pseudoephedrine HCl 120 mg
Indications/Uses
Symptoms associated w/ seasonal & perennial allergic rhinitis eg, nasal congestion, sneezing, rhinorrhoea, nasal & ocular pruritus.
Dosage/Direction for Use
Adult & childn ≥12 yr 1 tab bd (morning & evening) as long as symptoms last. Max: 2-3 wk.
Administration
May be taken with or without food: Swallow whole, do not chew/crush.
Contraindications
Hypersensitivity to cetirizine, pseudoephedrine, ephedrine or any other piperazine. Severe HTN or severe ischaemic heart disease, severe renal insufficiency, uncontrolled hyperthyroidism, severe arrhythmias, pheochromocytoma, elevated IOP or urinary retention; history of stroke & patients at high risk of developing haemorrhagic stroke. Concomitant administration of antihypertensives eg, β-blockers, sympathomimetics, dihydroergotamine or amphetamines. Patients receiving MAOI (up to 2 wk after discontinuation). Pregnancy & lactation.
Special Precautions
DM, hyperthyroidism, arterial HTN, tachycardia, cardiac arrhythmia, ischaemic heart disease, moderate renal/hepatic insufficiency. Prostatic hypertrophy or bladder outflow obstruction. Inflammatory bowel disease. Patients at risk of haemorrhagic stroke & hypercoagulability eg, inflammatory bowel disease. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive or operate machinery. Childn <12 yr. Elderly.
Adverse Reactions
Nervousness, insomnia; vertigo, dizziness, headache, somnolence; tachycardia; dry mouth, nausea; asthenia.
Drug Interactions
Alters disposition of ritonavir. Hypertensive crisis w/ MAOIs. Increased BP w/ dihydroergotamine or linezolid, bromocriptine, pergolide, lisuride, cabergoline, ergotamine, methylergotamine & other vasoconstrictors (phenylpropanolamine, phenylephrine, ephedrine). Reduced effects of β-adrenergic blockers, methyldopa, guanethidine & reserpine. Hypertensive effect is potentiated by TCAs. Increased absorption by antacids & proton-pump inhibitors. Reduced absorption by kaolin. May provoke or worsen ventricular arrhythmia w/ halogenated anaesth agents eg, chloroform, enflurane, isoflurane, cyclopropane, halothane. Not recommended in digitalized patients.
ATC Classification
R01BA52 - pseudoephedrine, combinations ; Belongs to the class of systemic sympathomimetic preparations used as nasal decongestants.
Presentation/Packing
Form
Zyrtec-D tab
Packing/Price
400's
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