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Bedaquiline - Oral - Patient Medicine Information

> Why do I need this medicine?
> How do I take this medicine?
> What should I do if I have forgotten to take this medicine?
> When should I not use this medicine?
> What should I take note of while taking this medicine?
> What side effects could I experience?
> Can I take this with other medicines?
> What special dietary instructions should I follow?
> How should I store this medicine?

 

Why do I need this medicine?

Bedaquiline is an antibiotic. It is used together with other medicines to treat a lung infection known as tuberculosis (TB).

How do I take this medicine?

Take Bedaquiline exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take it together with food or immediately after a meal. Try to take it at the same time each day.

Take Bedaquiline at regular intervals. You must complete the entire course of medicine. If you don't, the infection will not be properly controlled.

What should I do if I have forgotten to take this medicine?

If you miss a dose during the first 2 weeks of treatment, skip the missed dose and return to your normal dosing schedule. If you miss a dose from third week onwards, take the missed dose as soon as you remember and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.

When should I not use this medicine?

Do not take this medicine if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to Bedaquiline.

DO NOT take Bedaquiline with rifampicin, rifabutin, and rifapentine (medicines used to treat TB) and medicines for HIV infection, particularly efavirenz and etravirine.

What should I take note of while taking this medicine?

Inform your doctor if you have the following conditions:
  • thyroid disorder
  • syncope (loss of consciousness)
  • heart failure
  • bradyarrhythmia (slow, irregular or abnormal heartbeats)
  • congenital long QT syndrome (an inherited disease causing fast heartbeats)
  •  moderate or severe liver disease
  • severe kidney disease
Let your doctor know if you are pregnant or breastfeeding.

Notify your doctor if you consume large amounts of alcohol or if you are a frequent drinker.

What must I do to prevent spreading tuberculosis to other people?

Tuberculosis is spread through the air, especially when you cough, sneeze or laugh.

You may still be able to infect others while being treated for tuberculosis. Your doctor may tell you to stay at home to avoid passing the disease to other people. You may need to sleep in a room separate with other people and keep your room well-ventilated.

Always cover your mouth when you cough, sneeze or laugh. If you need to be around people for a long time, be sure to wear a mask that covers your mouth and nose to minimise the risk of passing the disease to other people.

Be sure to finish the course of medication according to your doctor's instructions.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.

Your doctor may need to perform ECG (a recording of the electrical activity of the heart) and blood tests to make sure that your heart and liver functions are normal before you take this medicine and thereafter depending on your doctor’s advice.

Sputum culture also needs to be done.

What side effects could I experience?

Bedaquiline may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: headache, nausea, vomiting, diarrhoea, chest pain, coughing up of blood, loss of appetite, rash, joint and muscle pain.

If you develop rashes, breathlessness, swollen mouth or eyes, stop taking Bedaquiline and inform your doctor quickly. These could be signs of an allergic reaction.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Can I take this with other medicines?

Do not take Bedaquiline with the following medicines:
  • rifampicin, rifapentine and rifabutin (medicines to treat TB)
  • efavirenz, etravirine (medicines for HIV infection)
Inform your doctor and pharmacist if you are taking any of these medicines:
  • antibiotics (e.g. ciprofloxacin, clarithromycin)
  • medicines to treat fungal infections e.g. fluconazole, ketoconazole
  • medicines for HIV infection e.g. lopinavir, ritonavir
  • clofazimine (medicine to treat leprosy)
  • herbal remedy used to relieve depression e.g. St. John’s wort
This list does not include all medicines that may interact with Bedaquiline.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.

What special dietary instructions should I follow?

Avoid alcohol.

How should I store this medicine?

Store in a cool, dry place away from the reach of children.

Keep in the original container to protect from light.

Medicines must not be used past the expiry date.

This information is independently developed by MIMS based on Bedaquiline - Oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2019 MIMS. All rights reserved. Powered by MIMS.com

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