MALAYSIA

Search result for

Dabrafenib - Oral - Patient Medicine Information

> Why do I need this medicine?
> How do I take this medicine?
> What should I do if I have forgotten to take this medicine?
> When should I not use this medicine?
> What should I take note of while taking this medicine?
> What side effects could I experience?
> Can I take this with other medicines?
> What special dietary instructions should I follow?
> How should I store this medicine?

 

Why do I need this medicine?

Dabrafenib is used on its own or together with trametinib to treat melanoma (tumour associated with skin cancer) that has spread to other parts of the body or which cannot be removed by surgery.

This medicine may also be used on its own or together with trametinib to treat a certain type of lung cancer (non-small cell lung cancer).

How do I take this medicine?

Take Dabrafenib exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Take this medicine at regular intervals, approximately 12 hours apart. Take it on an empty stomach, at least 1 hour before or 2 hours after a meal. Swallow it whole. Do not chew, crush or open the capsule. Try to take it at the same time each day.

The dose of Dabrafenib will be decided by your doctor. Your doctor will advise you on the course of your treatment depending on your condition, effectiveness of the therapy, and your tolerability to this medicine.

Dabrafenib must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.

What should I do if I have forgotten to take this medicine?

Take the missed dose as soon as you remember. If it is within 6 hours before the next dose is due, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.

When should I not use this medicine?

Do not take this medicine if you are pregnant. If you become pregnant while on Dabrafenib therapy, alert your doctor immediately. This medicine may cause harm to your unborn child. It is important that you do not get pregnant while taking this medicine. You must use proven birth control methods during Dabrafenib therapy and for a certain period of time after stopping the treatment. Birth control medicines containing hormones may not be effective. You may wish to discuss other reliable methods of birth control with your doctor.

Do not breastfeed while you are being treated with this medicine.

What should I take note of while taking this medicine?

Inform your doctor if you have the following conditions:
  • liver disease
  • kidney disease
  • diabetes
  • heart disease e.g. heart rhythm disorder, heart failure
  • G6PD deficiency (an inherited blood disorder that affects the red blood cell)
  • eye problems
  • lung or breathing problems
  • different type of cancer other than melanoma or non-small cell lung cancer
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • You may need to have routine tests (e.g. complete blood count, blood glucose, electrolyte, kidney and liver function test, eye examination). Your doctor will advise you about how often you will need to have these tests.
  • Regular monitoring of signs and symptoms of infections or toxicity may be needed while you are being treated with this medicine.
  • Skin evaluation, pregnancy test, counselling on fertility and family planning may be needed prior treatment initiation to check the appropriateness of Dabrafenib therapy.

What side effects could I experience?

Dabrafenib may cause tiredness or some problems with your eyesight. If affected, do not drive or take part in any activity in which you need to be alert or need to see clearly.

Other side effects may include any of the following: headache, diarrhoea, constipation, hair thinning or loss, muscle pain, joint pain, limb pain, thickening of the outer layer of the skin, and skin rash.

If you develop rashes, breathlessness, swollen mouth or eyes, stop taking Dabrafenib and inform your doctor quickly. These could be signs of an allergic reaction.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • abnormal growth in the skin, skin sore or reddish bump that bleeds or does not heal, skin lesions, new wart, change in the size or colour of a mole
  • persistent fever (body temperature above 38.5°C) or fever complicated by low blood pressure, chills, dehydration or kidney failure
  • signs of bleeding e.g. vomiting blood or vomit coffee-ground-like vomitus, coughing up blood, black, red or tarry stools, blood in the urine, bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth), or unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own)
  • signs of high blood sugar level e.g. confusion, tiredness, increased thirst or hunger, frequent urination, breath that smells like fruit
  • signs of heart problems e.g. irregular, pounding or racing heartbeat, shortness of breath, swelling of the legs, ankles or feet, sudden weight gain, feeling lightheaded
  • eye problems e.g. eye irritation, pain, redness or swelling, blurred vision, any change in your eyesight, increased sensitivity to light
  • signs of liver problems e.g. yellowing of the skin or eyes, dark urine, light coloured stool, lack of appetite, nausea, vomiting, stomach pain
  • signs of infection e.g. fever, chills, night sweats, flu-like symptoms, sore throat, mouth sore, tiredness, persistent cough, painful or burning sensation when urinating
  • severe stomach pain
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Can I take this with other medicines?

Inform your doctor or pharmacist if you are taking any of these medicines:
  • blood-thinning medicines e.g. warfarin
  • certain antibiotics e.g. clarithromycin, telithromycin
  • medicines to treat fungal infection e.g. itraconazole, ketoconazole, posaconazole, voriconazole
  • medicines for HIV infection e.g. atazanavir, efavirenz, etravirine, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir
  • medicines to treat TB (infection known as tuberculosis) e.g. rifampicin
  • medicines for epilepsy (fits or seizures) e.g. carbamazepine, phenobarbital, phenytoin
  • medicines for heart disease or high blood pressure e.g. verapamil
  • medicines to treat depression e.g. nefazodone
  • medicines used in organ transplant or certain immune disorders e.g. ciclosporin, sirolimus, tacrolimus
  • medicines for moderate to severe pain e.g. fentanyl
  • cholesterol-lowering medicines e.g. atorvastatin, simvastatin, gemfibrozil
  • medicines that reduce stomach acid production e.g. omeprazole
  • herbal supplement e.g. St. John’s wort
Inform your doctor if you are currently taking birth control pills as this can reduce the effectiveness of Dabrafenib. You should not stop or start any birth control pills without first informing your doctor. Ask your doctor about using non-hormonal birth control as an alternative while being treated with this medicine.

This list does not include all medicines that may interact with Dabrafenib.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.

What special dietary instructions should I follow?

Avoid alcohol.

How should I store this medicine?

Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

As this is a cancer medicine, always return any unused or expired medicine to the clinic, hospital or pharmacy for disposal. Do not throw it away in the household waste.

This information is independently developed by MIMS based on Dabrafenib - Oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2019 MIMS. All rights reserved. Powered by MIMS.com

Editor's Recommendations

Drug Index A to Z
Browse Alphabetically (Brand)
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Browse Alphabetically (Generic)
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
 
Connect With Us
 
Download FREE MIMS Apps
 
Node#1
Please wait...