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Dolutegravir - Oral - Patient Medicine Information

> Why do I need this medicine?
> How do I take this medicine?
> What should I do if I have forgotten to take this medicine?
> When should I not use this medicine?
> What should I take note of while taking this medicine?
> What side effects could I experience?
> Can I take this with other medicines?
> What special dietary instructions should I follow?
> How should I store this medicine?

 
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Why do I need this medicine?

Dolutegravir is used together with other medicines to slow down the progression of Human Immunodeficiency Virus type 1 (HIV-1) infection.

How do I take this medicine?

Take Dolutegravir exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment regimen depending on your age, weight and condition.

If you are taking antacids (medicines to neutralize stomach acids), laxatives (medicines for constipation), calcium or iron-containing medicines or supplements, take Dolutegravir 2 hours before or 6 hours after taking these medicines.

Dolutegravir must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.

What should I do if I have forgotten to take this medicine?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.

When should I not use this medicine?

Do not take this medicine if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to Dolutegravir or any other similar medicines.

DO NOT take Dolutegravir with medicines used to treat heart rhythm problems such as dofetilide.

What should I take note of while taking this medicine?

Inform your doctor if you have the following conditions:
  • hepatitis B or C infection
  • kidney disease
  • liver disease
Let your doctor know if you are pregnant.

Inform your doctor if you are breastfeeding. It is best that you do not breastfeed as HIV passes into the breast milk. Avoid breastfeeding in order to reduce the risk of passing HIV to your baby. It is recommended to give your baby commercial infant formula provided that you have access to clean water and facilities.

Dolutegravir does not reduce your risk of passing HIV infection to others through sexual contact or through contamination with infected blood. Ensure that you use proper precautions to avoid spreading HIV infection to others.

Both this medicine and HIV may weaken your immune system, leaving you more vulnerable to infections. Avoid crowded places or those who are sick to minimise the risk of catching an infection. While undergoing treatment, you may develop other infections or experience other health problems. Always keep your doctor updated on your condition.

A certain enzyme called UGT1A1 is involved in the breakdown of Dolutegravir in the body. Individuals who have poor UGT1A1 enzyme activity, known as UGT1A1 poor metabolisers, may have an increased exposure to this medicine. If you know you have this gene type, inform your doctor.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly. You may need to have routine blood tests (e.g. liver function test, cholesterol levels, amount of HIV in a blood sample) while you are being treated with this medicine. Your doctor will advise you about how often you will need to have these tests.

What side effects could I experience?

Dolutegravir may cause dizziness. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: headache, tiredness, diarrhoea, nausea, vomiting, stomach wind, stomach pain or discomfort, and difficulty sleeping.

If you develop rashes, breathlessness, swollen mouth or eyes, stop taking this medicine and inform your doctor quickly. These could be signs of an allergic reaction.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • signs of infection e.g. fever, chills, night sweats, flu-like symptoms, sore throat, mouth sore, persistent cough, painful or burning sensation when urinating
  • signs of liver problems e.g. yellowing of the skin or eyes, dark urine, light coloured stool, lack of appetite, nausea, vomiting, stomach pain
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Can I take this with other medicines?

Do not take Dolutegravir with medicines for irregular heartbeat e.g. dofetilide.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.

What special dietary instructions should I follow?

Avoid taking Dolutegravir together with high-fat foods. Ask your doctor about the type of foods you need to avoid.

Avoid alcohol.

How should I store this medicine?

Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

This information is independently developed by MIMS based on Dolutegravir - Oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2019 MIMS. All rights reserved. Powered by MIMS.com

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