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Estradiol - Transdermal - Patient Medicine Information

> Why do I need this medicine?
> How do I use this medicine?
> What should I do if I have forgotten to use this medicine?
> When should I not use this medicine?
> What should I take note of while using this medicine?
> What side effects could I experience?
> Can I use this with other medicines?
> What special dietary instructions should I follow?
> How should I store this medicine?

 

Why do I need this medicine?

Estradiol is used as a hormone replacement therapy (HRT) in menopausal women. It is used to treat symptoms associated with menopause such as hot flushes, sleep disturbances, mood swings and vaginal dryness or irritation.

This medicine may also be used to prevent osteoporosis in menopausal women.

Estradiol may be used to treat other conditions as decided by your doctor.

How do I use this medicine?

Use Estradiol exactly as directed by your doctor or according to the instructions on the label. Do not use more or less than instructed by your doctor.

Estradiol transdermal is available as a patch, gel or spray. This medicine is to be applied on the skin. It will be delivered into the body through the skin.

To apply Estradiol transdermal patch:
  1. Remove the patch from the pouch with clean and dry hands.
  2. Remove the protective strip and apply the sticky side of the patch to a clean, dry and intact area of the skin. Apply either on your lower abdomen or upper buttocks. Alternate application area every time. Do not apply on or near your breasts. Avoid areas where the patch may be rubbed off by your clothes (e.g. waistline).
  3. Firmly press the patch onto the skin with your palm.
  4. Hold for about 10 seconds to ensure the patch sticks well to the skin.
The patch will not fall out when you are bathing or swimming. However, if it does fall out, put the same patch or you may use a new patch and continue the application schedule.

To apply Estradiol transdermal gel as a single-use packet:
  1. Wash and dry your hands.
  2. Squeeze the entire contents of the packet onto a clean, dry and intact area of the skin. Apply and gently spread a thin layer of the gel on your upper thigh. Alternate application area every time. Do not apply on or near your breasts.
  3. Allow the gel to dry before dressing.
  4. Wash and dry your hands after each application.
To apply Estradiol transdermal gel as a multiple-use pump:
  1. Wash and dry your hands.
  2. If it is your first time using the pump, prime it first by fully pressing its head down 3 times. After priming, the pump is now ready to use.
  3. Hold the pump in one hand and place your other hand under the spout to collect the gel. One complete pump will dispense the same amount of gel each time.
  4. Press the pump firmly and fully. Apply to a clean, dry and intact area of the skin. Apply and gently spread a thin layer of the gel on your arms, shoulder or upper thigh. Alternate application area every time. Do not apply on or near your breasts.
  5. Allow the gel to dry before dressing.
  6. Wash and dry your hands after each application.
To apply Estradiol transdermal spray:
  1. If it is your first time using the spray, prime it (with the applicator on an upright position and the cover still on) first by fully pressing its pump 3 times. After priming, the spray is now ready to use.
  2. Remove the cover on the spray. Rest the cone part of the spray flat against your skin.
  3. Spray the specified amount by pressing the pump firmly and fully. One complete spray will dispense the same amount of product each time.
  4. Spray to a clean, dry, and intact area of the skin. Apply on the inner part of your forearm. Alternate application area every time. Do not apply on or near your breasts.
  5. Allow to dry before dressing.
Estradiol must be used regularly for it to be effective. Continue using it even when you feel better. Do not stop using it unless instructed by your doctor.

What should I do if I have forgotten to use this medicine?

Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

Do not use more than what is instructed by your doctor to make up for the missed dose.

If you often forget to apply your medicine, let your doctor and pharmacist know.

When should I not use this medicine?

Alert your doctor if you have the following conditions:
  • blood clot disorder
  • liver disease
  • recent heart attack
  • recent stroke
  • known, suspected or history of cancer of the breast, lining of the womb or ovaries
  • thickening of the womb lining
  • unexplained or unusual vaginal bleeding
  • porphyria (inherited disorder that may cause skin or nerve problems)
as this medicine may not be suitable for you.

Do not use Estradiol if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with this medicine, alert your doctor immediately. Estradiol may cause harm to your unborn child. You must use proven birth control methods while using this medicine.

What should I take note of while using this medicine?

Inform your doctor if you have the following conditions:
  • epilepsy (fits or seizures)
  • asthma
  • migraine
  • kidney disease
  • heart disease or risk factors for heart disease e.g. high blood pressure, diabetes, high cholesterol - gallbladder disease
  • thyroid problems e.g. low activity of the thyroid gland
  • low calcium level in the blood
  • otosclerosis (hearing disorder due to growth of bone in the inner ear)
  • systemic lupus erythematosus (autoimmune disease that causes inflammation)
Let your doctor know if you are breastfeeding.

If you are going for surgery or any laboratory tests, inform your doctor that you are using Estradiol.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Screening for cancer, pregnancy test, personal and family medical history assessment may be needed to check the appropriateness of Estradiol treatment.
  • You may need to have routine tests (e.g. breast and cervix exam). Your doctor will advise you about how often you will need to have these tests.
  • Regular monitoring of blood pressure, blood sugar level and thyroid function may be needed while you are being treated with this medicine.

What side effects could I experience?

Estradiol may cause any of the following side effects: headache, nausea, stomach pain, stomach wind, bloating, difficulty sleeping, back pain, skin rash, itching, vaginal discharge or irritation, painful menstruation, breast pain or tenderness, and application site reactions.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • difficulty breathing or chest discomfort
  • severe headache or migraine
  • visual disturbances
  • breast lumps, dimples in the skin around the breast, or changes in the nipple
  • abnormal vaginal bleeding
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Can I use this with other medicines?

Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines to treat TB (infection known as tuberculosis) e.g. rifampicin
  • medicines for epilepsy (fits or seizures) e.g. phenobarbital, phenytoin, carbamazepine
  • medicines for HIV infection e.g. ritonavir, nevirapine, efavirenz
  • certain antibiotics e.g. clarithromycin, erythromycin
  • medicines to treat fungal infection e.g. itraconazole, ketoconazole
  • St John's wort (herbal medicine)
This list does not include all medicines that may interact with Estradiol.

Always notify your doctor or pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.

What special dietary instructions should I follow?

Avoid alcohol.

Avoid excessive consumption (more than 1 litre a day) of grapefruit juice.

How should I store this medicine?

Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

This information is independently developed by MIMS based on Estradiol - Transdermal and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2019 MIMS. All rights reserved. Powered by MIMS.com

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