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Everolimus - Oral - Patient Medicine Information

> Why do I need this medicine?
> How do I take this medicine?
> What should I do if I have forgotten to take this medicine?
> When should I not use this medicine?
> What should I take note of while taking this medicine?
> What side effects could I experience?
> Can I take this with other medicines?
> What special dietary instructions should I follow?
> How should I store this medicine?

 
Available Brands

Other Known Brands
  • Afinitor    

Why do I need this medicine?

Everolimus is used on its own or together with other medicines to treat certain types of neuroendocrine tumours that originate from the stomach, bowels, lungs or pancreas, or advanced cancer of the breast or kidney, where previous therapy has failed.

This medicine can also be used on its own or together with other medicines to prevent organ rejection in kidney, heart or liver transplant.

How do I take this medicine?

Take Everolimus exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food, but it should consistently be taken the same way (e.g. always with food or always without food). Try to take it at the same time each day.

This medicine is available as a tablet or dispersible tablet.

If you are taking the tablet, swallow it whole with a full glass of water. Do not divide, chew or crush the tablet.

Dispersible tablets are to be taken as a suspension. The suspension may be prepared using an oral syringe or a small glass.

When preparing the suspension in an oral syringe, follow these steps:
  1. Place the required dose in a 10-mL syringe. A maximum dose of 10 mg can be prepared per syringe. If higher doses are needed, prepare an additional syringe. Do not break or crush the tablets.
  2. Draw approximately 5 mL of water and 4 mL of air into the syringe.
  3. Place the filled syringe into a container (tip up) for 3 minutes, until the tablets are in suspension.
  4. Gently invert the syringe 5 times immediately before administration. Do not shake.
  5. After administration of the prepared suspension, draw approximately 5 mL of water and 4 mL of air into the same syringe, and swirl the contents gently to suspend remaining particles. Administer the entire contents of the syringe.
If you are preparing the suspension in a glass, follow these steps:
  1. Place the required dose into a small drinking glass (maximum size 100 mL) containing approximately 25 mL of water. A maximum dose of 10 mg can be prepared per glass. If higher doses are required, prepare an additional glass. Do not break or crush the tablets.
  2. Allow 3 minutes for a suspension to occur.
  3. Stir the contents gently with a spoon, immediately before drinking.
  4. After administration of the prepared suspension, add 25 mL of water and stir with the same spoon to re-suspend remaining particles. Administer the entire contents of the glass.
If you have problems or do not understand the instructions, ask your doctor or pharmacist.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the course of your treatment depending on your condition and response to the medication.

Everolimus must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.

What should I do if I have forgotten to take this medicine?

If you miss a dose and it is within 6 hours after your regular schedule, take the missed dose and return to your normal dosing schedule.

If it is more than 6 hours after your regular schedule, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.

When should I not use this medicine?

Do not take this medicine if you ever had an allergic reaction (rashes, breathlessness, swollen eyes) to Everolimus and similar medicines such as sirolimus, pimecrolimus or tacrolimus.

Do not breastfeed while you are being treated with this medicine and for 2 weeks after the last dose.

What should I take note of while taking this medicine?

Inform your doctor if you have the following conditions:
  • hyperlipidaemia (excessive amount of cholesterol in the blood)
  • diabetes
  • liver disease
It is important that you do not get pregnant while being treated with Everolimus. You may wish to discuss birth control methods with your doctor or pharmacist.

If you are going to have an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Regular blood tests to check the amount of blood cells in your body
  • Routine tests to check your kidney and liver function, cholesterol/sugar levels 
Your doctor will advise you about how often you will need to have these tests.

What side effects could I experience?

Everolimus may make you feel unusually tired. If affected, do not drive or take part in any activity in which you need to be alert or need to see clearly.

Other side effects include any of the following: inflammation of mouth or lips, rash, diarrhoea, fever, nausea, decreased appetite, taste alterations, itch, nose bleed, cough, difficulty sleeping, headache, high blood pressure, dry mouth, joint pain and stomach pain.

Everolimus may also make your skin more sensitive to sunlight. Apply sunscreen when going outdoors and avoid prolonged exposure to sunlight and UV lamps.

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • rashes, breathlessness, swelling of the face, eyes or mouth
  • fever and chills
  • coughing, wheezing, difficulty breathing
  • shortness of breath, chest pain or coughing up blood
  • decreased urine output, swelling in the legs, feeling confused, back pain
This medicine will cause the level of your red blood cells, white blood cells and platelets to drop.

Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.

White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Alert your doctor if you have a fever, or a cough or flu that does not go away.

Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Can I take this with other medicines?

Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines used in organ transplant or certain immune disorders e.g. ciclosporin
  • medicines for fungal infection e.g. ketoconazole, fluconazole, itraconazole
  • certain antibiotics e.g. erythromycin, clarithromycin
  • rifampicin (medicine to treat TB)
  • medicines for epilepsy (fits or seizures) e.g. carbamazepine, phenobarbital, phenytoin
  • medicines for high blood pressure e.g. ramipril, lisinopril, enalapril, verapamil, diltiazem
  • medicines to treat HIV infection e.g. ritonavir, efavirenz, nevirapine, fosamprenavir
  • St John’s wort (herbal medicine used to treat depression and other conditions)
This list does not include all medicines that may interact with Everolimus.

Avoid vaccinations during treatment with Everolimus.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.

What special dietary instructions should I follow?

Avoid alcohol.

Avoid excessive consumption of grapefruit or grapefruit juice.

How should I store this medicine?

Store in a cool, dry place away from the reach of children. Protect from light and moisture.

Medicines must not be used past the expiry date.

This information is independently developed by MIMS based on Everolimus - Oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2019 MIMS. All rights reserved. Powered by MIMS.com

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