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Glyceryl Trinitrate - Rectal - Patient Medicine Information

> Why do I need this medicine?
> How do I use this medicine?
> What should I do if I have forgotten to use this medicine?
> When should I not use this medicine?
> What should I take note of while using this medicine?
> What side effects could I experience?
> Can I use this with other medicines?
> What special dietary instructions should I follow?
> How should I store this medicine?

 

Why do I need this medicine?

Glyceryl Trinitrate (GTN) rectal ointment belongs to a group of medicines known as nitrates and is used to relieve the pain caused by chronic (long-term) anal fissures. Anal fissures are tears or breaks in the skin lining of the anal canal.

How do I use this medicine?

1. Wash your hands thoroughly.

2. Place your finger alongside the dosing line printed on the outside carton of the ointment tube.

3. Squeeze the tube to release a length of ointment onto your finger corresponding to the 2.5 cm line indicated on the carton.

4. Gently insert your finger into the anal canal. Apply the ointment around the area in a gentle, circular motion. The finger must be inserted up to the first finger joint (about 1 cm) into the anus.

5. Wash your hands after applying the ointment. You may use a finger cot to apply the ointment instead of your bare finger.

Apply the ointment exactly as directed by your doctor or according to the instructions on the label. DO NOT apply larger amounts or more frequently than instructed by your doctor.

What should I do if I have forgotten to use this medicine?

Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to apply your medicine, let your doctor and pharmacist know.

When should I not use this medicine?

It is very important that you DO NOT use GTN with medicines used to treat impotence and/or pulmonary arterial hypertension (high blood pressure in the blood vessels leading to the lungs), such as sildenafil (e.g. Viagra®), tadalafil (e.g. Cialis®) and vardenafil (e.g. Levitra®).

Alert your doctor if you have the following conditions:

- history of heart problems e.g. pericarditis (inflammation of the heart), valve stenosis (narrowing of the heart valves)
- increased pressure in the skull due to bleeding in the brain or head injury
- migraine
- low blood pressure
- severe anaemia (low red blood cell counts)
- glaucoma (increased eye pressure)
as GTN may not be suitable for you.

What should I take note of while using this medicine?

Inform your doctor if you have the following:

- liver disease
- kidney disease
- haemorrhoids (piles) which seem to bleed more than usual

Let your doctor know if you are pregnant or breastfeeding.

GTN rectal ointment is not meant to be used in children younger than 18 years old.

What side effects could I experience?

If you are using GTN rectal ointment for the first time, you may experience headaches and nausea. If necessary, you may take some simple painkillers for your headache. There may also be some temporary discomfort such as itching or burning sensation in the anal region.

You may feel dizzy when getting up from a sitting or lying down position; hence get up slowly when doing so. If you feel dizzy, sit or lie down until you feel better. Do not drive or take part in any activity in which you need to be alert.

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Can I use this with other medicines?

DO NOT use GTN with medicines used to treat impotence and/or pulmonary arterial hypertension (high blood pressure in the blood vessels leading to the lungs), such as sildenafil (e.g. Viagra®), tadalafil (e.g. Cialis®) and vardenafil (e.g. Levitra®).

Inform your doctor and pharmacist if you are taking any of these medicines:

- medicines that can lower blood pressure e.g. enalapril, atenolol
- other types of nitrates
- medicines to treat depression e.g. amitriptyline
- apomorphine (medicine for Parkinson's disease)
- dihydroergotamine (medicine for migraine)
- acetylcysteine (medicine for phlegm)

This list does not include all medicines that may interact with GTN.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics, such as traditional Chinese medicine, supplements and medicines that you buy without a prescription.

What special dietary instructions should I follow?

Avoid alcohol as it may trigger or worsen the dizziness caused by GTN.

How should I store this medicine?

Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

Discard 8 weeks after opening.

This information is independently developed by MIMS based on Glyceryl Trinitrate - Rectal and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2019 MIMS. All rights reserved. Powered by MIMS.com

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