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Osimertinib - Oral - Patient Medicine Information

> Why do I need this medicine?
> How do I take this medicine?
> What should I do if I have forgotten to take this medicine?
> What should I take note of while taking this medicine?
> What side effects could I experience?
> Can I take this with other medicines?
> What special dietary instructions should I follow?
> How should I store this medicine?

 
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Why do I need this medicine?

Osimertinib is used to treat a certain type of lung cancer (non-small cell lung cancer) that has spread to other parts of the body which is caused by a defect in a gene.

This medicine reduces the size of the tumour by stopping cancer cells from growing.

How do I take this medicine?

Take Osimertinib exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

You may take this medicine with or without food. Try to take it at the same time each day.

Swallow the tablet whole with a glass of water. Do not chew or crush the tablet.

If you have difficulty swallowing tablet(s), disperse the tablet in 50-60 mL of non-carbonated water. Stir the water until the tablet breaks into small pieces. Drink it immediately after mixing. The tablet will not completely dissolve. To make sure that you have taken all of the medicine, you may rinse the glass with water, and drink it immediately.

The dose of this medicine will be decided by your doctor. Your doctor will advise you on the dosage and treatment timeframe depending on your condition and response to the medication.

Osimertinib must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.

What should I do if I have forgotten to take this medicine?

Take the missed dose as soon as you remember. If it is less than 12 hours before the next dose is due, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know.

What should I take note of while taking this medicine?

Inform your doctor if you have the following conditions:
  • heart disease or risk factors for heart problems
  • other lung disease or breathing problems e.g. inflamed lungs
Let your doctor know if you are pregnant or breastfeeding.

It is important that you do not get pregnant or father a child during the treatment. You and your partner must use proven birth control methods while taking these medicines and for a period of time after stopping the treatment. You may wish to discuss birth control methods with your doctor or pharmacist.

Be sure to check with your doctor or pharmacist before giving Osimertinib to an elderly. Elderly may be more sensitive to the side effects.

If you are going for an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
  • Prior to treatment initiation, certain tests (e.g. pregnancy test, tumour or plasma specimen test) may be done to check the appropriateness of this medication.
  • You may need to have routine monitoring of ECG and electrolytes while you are being treated with this medicine. Your doctor will advise you about how often you need to have these tests.

What side effects could I experience?

Osimertinib may cause any of the following side effects: diarrhoea, rash, dry skin, severe itching, mouth sores, and changes in your nails (e.g. tenderness, redness, pain, inflammation, brittleness, separation from nailbed, and shedding of nails).

Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
  • difficulty in breathing, cough or fever
  • abnormal heartbeat, pounding or racing heart, shortness of breath, swelling of ankles, feet or legs
  • watery eyes, eye pain, redness, or sensitivity to light, vision changes
This medicine may cause the level of your red blood cells, white blood cells and platelets to drop.

Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.

White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Alert your doctor if you have a fever, or a cough or flu that does not go away.

Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Can I take this with other medicines?

Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for epilepsy (fits or seizures) e.g. phenytoin, carbamazepine
  • medicines to treat TB (infection known as tuberculosis) e.g. rifampicin
  • medicines for HIV infection e.g. efavirenz, etravirine
  • bosentan (medicine for high blood pressure in the lungs)
  • modafinil (medicine for sleep disorder)
  • St. John’s wort (herbal supplement)
This list does not include all medicines that may interact with Osimertinib.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.

What special dietary instructions should I follow?

Avoid alcohol.

How should I store this medicine?

Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

As this is a cancer medicine, always return any unused or expired tablets to the clinic, hospital or pharmacy for disposal. Do not throw it away in the household waste.

Keep the bottle tightly closed after use.

This information is independently developed by MIMS based on Osimertinib - Oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2019 MIMS. All rights reserved. Powered by MIMS.com

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