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Ribociclib - Oral - Patient Medicine Information

> Why do I need this medicine?
> How do I take this medicine?
> What should I do if I have forgotten to take this medicine?
> When should I not use this medicine?
> What should I take note of while taking this medicine?
> What side effects could I experience?
> Can I take this with other medicines?
> What special dietary instructions should I follow?
> How should I store this medicine?

 
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Why do I need this medicine?

Ribociclib is used on its own or together with other medicines to treat breast cancer which have spread from the original site to nearby areas or some parts of the body for women who are about to be or are menopause (no longer have menstrual period).

How do I take this medicine?

Take Ribociclib exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.

Try to take it at the same time each day, preferably in the morning.

Ribociclib is usually taken for 21 days followed by a 7-day rest period when no medicine is taken. This is a one “cycle” of treatment. The dose of this medicine will be decided by your doctor. Your doctor will advise you on the course of your treatment depending on your condition, effectiveness of the therapy, and your tolerability to this medicine. Follow your doctor's instructions carefully. Always ask your doctor if you are not sure on how to take your medicine.

What should I do if I have forgotten to take this medicine?

If you miss a dose or vomit after taking Ribociclib, skip the missed dose and return to your normal dosing.

DO NOT double a dose to make up for a missed dose.

If you often forget to take your medicine, let your doctor and pharmacist know.

When should I not use this medicine?

Do not take Ribociclib if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with Ribociclib, alert your doctor immediately. This medicine may cause harm to your unborn child. You must use proven birth control methods while taking this medicine.

It is important that you do not get pregnant while being treated with this medicine. You may wish to discuss birth control methods with your doctor or pharmacist. Avoid pregnancy for at least 3 weeks after you stop taking this medicine.

Do not breastfeed while you are being treated with this medicine.

What should I take note of while taking this medicine?

Inform your doctor if you have the following conditions:
  • severe kidney disease
  • moderate to severe liver disease
Why is it important to keep my appointments with the doctor?

Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.

For as long as you are taking this medicine, you may need to have regular blood tests (e.g. complete blood count with differential) to check your body’s response to the medicine and the health of your heart and liver. Your doctor will advise you how often you need to have them.
  • Regular monitoring of signs and symptoms of infections or toxicity may be needed while you are being treated with this medicine.
  • Pregnancy test may be needed prior treatment initiation to check the appropriateness of Ribociclib therapy.

What side effects could I experience?

Ribociclib may cause tiredness, dizziness or vertigo. If affected, do not drive or take part in any activity in which you need to be alert.

Other side effects include any of the following: headache, cough, nausea, vomiting, diarrhoea, constipation, back pain, stomach pain, indigestion, tiredness, fever, loss of appetite, change of taste, rashes or itchiness, pain in the throat up to the tongue, dry skin, eyes or mouth; excessive tearing of the eyes, redness of the skin, white patches on the skin, alopecia (spot baldness), swelling of ankles, feet and hand; and difficulty of breathing.

Some side effects may be serious, although they are not common. Alert your doctor quickly if you experience:
  • fainting or sudden loss of consciousness, seizures
  • yellowing of the skin or eyes
This medicine will cause the level of your red blood cells, white blood cells and platelets to drop.

Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.

White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Alert your doctor if you have a fever, or a cough or flu that does not go away.

Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Alert your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).

Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.

Can I take this with other medicines?

Inform your doctor and pharmacist if you are taking any of these medicines:
  • medicines for irregular heartbeat e.g. amiodarone, disopyramide, quinidine
  • medicines for fits or seizure e.g. carbamazepine, phenytoin
  • medicines to treat fungal infection e.g. itraconazole, ketoconazole
  • antibiotics e.g. clarithromycin, moxifloxacin
  • medicine for HIV infection e.g. indinavir
  • medicine for malaria e.g. chloroquine
  • medicine to treat depression e.g. nefazodone
  • medicine for mood disorders e.g. pimozide
  • other medicines such as tamoxifen, ergotamine, cisapride
This list does not include all medicines that may interact with Ribociclib.

Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements and medicines that you buy without a prescription.

What special dietary instructions should I follow?

Avoid alcohol. Consuming large amount of alcohol is damaging to your liver.

Avoid St John's wort.

Avoid excessive consumption (more than 1 litre a day) of grapefruit juice.

How should I store this medicine?

Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

As this is a cancer medicine, always return any unused or expired medicine to the clinic, hospital or pharmacy for disposal. Do not throw it away in the household waste.

This information is independently developed by MIMS based on Ribociclib - Oral and is provided for your reference only. It is not a replacement for and should only be used in conjunction with full consultation with a licensed healthcare professional, the information provided by your pharmacist and/or the manufacturer of the medication. It may not contain all the available information you require and cannot substitute professional medical care, nor does it take into account all individual circumstances. Although great effort has been made to ensure content accuracy, we shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2019 MIMS. All rights reserved. Powered by MIMS.com

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