Acamprosate


Concise Prescribing Info
Indications/Uses
Alcohol abstinence.
Dosage/Direction for Use
Adult : PO 18-65 yr ≥60 kg: 666 mg tid; <60 kg: 666 mg at breakfast, 333 mg at midday and 333 mg at night.
Dosage Details
Oral
Alcohol abstinence
Adult: 18-65 yr ≥60 kg: 666 mg tid; <60 kg: 666 mg at breakfast, 333 mg at midday and 333 mg at night. Treatment should be started as soon as possible after the withdrawal period; maintain even if patient relapses. Recommended duration: 1 yr.
Elderly: >65 yr Not recommended.
Renal Impairment
CrCl (mL/min) Dosage
<30 Contraindicated.
30-50 Initially, 333 mg tid.
Hepatic Impairment
Severe: Contraindicated.
Administration
Should be taken with food. Take at meal times.
Contraindications
Severe hepatic or renal impairment (CrCl <30 mL/min). Lactation.
Special Precautions
Patient w/ suicidal ideation. Moderate renal impairment (CrCl 30-50 mL/min). Elderly (>65 yr). Pregnancy.
Adverse Reactions
Nausea, vomiting, diarrhoea, asthenia, abdominal pain, pruritus, maculopapular rash, depression, fluctuations in libido. Rarely, bullous skin reactions, hypersensitivity reactions including urticaria, angioedema and anaphylaxis.
Patient Counseling Information
This drug may cause CNS depression, if affected, do not drive or operate machinery.
MonitoringParameters
Monitor renal function; signs of depression and/or suicidal thinking.
Overdosage
Symptoms: Diarrhoea; hypercalcaemia may be considered in chronic overdose. Management: Symptomatic and supportive treatment.
Drug Interactions
Increased plasma concentrations w/ naltrexone.
Food Interaction
Food reduces absorption.
Action
Description: Acamprosate affects the balance of GABA and glutamate neurotransmitters by decreasing glutamatergic transmission and modulation of neuronal hyperexcitability.
Pharmacokinetics:
Absorption: Slowly absorbed from the GI tract. Reduced absorption w/ food. Bioavailability: Approx 11%. Time to peak plasma concentration: 3-8 hr.
Distribution: Crosses the blood-brain barrier. Volume of distribution: Approx 1 L/kg.
Excretion: Via urine as unchanged drug. Elimination half-life: 20-33 hr.
Chemical Structure

Chemical Structure Image
Acamprosate

Source: National Center for Biotechnology Information. PubChem Database. Acamprosate, CID=71158, https://pubchem.ncbi.nlm.nih.gov/compound/Acamprosate (accessed on Jan. 20, 2020)

Storage
Store at 25°C.
ATC Classification
N07BB03 - acamprosate ; Belongs to the class of drugs used in the management of alcohol dependence.
References
Acamprosate Calcium Tablet, Delayed Release (Glenmark Pharmaceuticals Inc., USA). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 23/11/2015.

Anon. Acamprosate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 23/11/2015.

Buckingham R (ed). Acamprosate Calcium. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 23/11/2015.

McEvoy GK, Snow EK, Miller J et al (eds). Acamprosate Calcium. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 23/11/2015.

Disclaimer: This information is independently developed by MIMS based on Acamprosate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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