Acipimox


Concise Prescribing Info
Indications/Uses
Hyperlipidaemias.
Dosage/Direction for Use
Adult : PO 250 mg bid or tid. Max 1,200 mg/day.
Dosage Details
Oral
Hyperlipidaemias
Adult: 250 mg bid or tid. Max: 1,200 mg daily.
Renal Impairment
CrCl (mL/min) Dosage
<30 Contraindicated.
30-60 250 mg 1-2 times daily.
Administration
Should be taken with food. Take w/ or after meals.
Contraindications
Peptic ulcer. Severe renal impairment (CrCl <30 mL/min).
Special Precautions
Renal impairment (CrCl 30-60 mL/min).
Adverse Reactions
Peripheral vasodilatation, resulting in flushing, itching and sensation of heat; rash, erythema, heartburn, epigastric pain, nausea, diarrhoea, headache, myalgia, arthralgia, dry eye, malaise, myositis. Rarely, urticaria, angioedema, bronchospasm.
MonitoringParameters
Monitor hepatic and renal function. Measure lipid profile before treatment and serum lipids periodically.
Drug Interactions
Risk of myopathy is increased when nicotinic acid is given concomitantly w/ a statin, as acipimox is structurally related to nicotinic acid, caution should be taken when used w/ such agents.
Action
Description: Acipimox inhibits the release of fatty acids from adipose tissue and reduces the blood concentrations of VLDL and LDL w/ a subsequent overall reduction in triglyceride and cholesterol levels.
Pharmacokinetics:
Absorption: Rapidly and completely absorbed from the GI tract. Time to peak plasma concentration: W/in 2 hr.
Excretion: Via urine. Plasma half-life: Approx 2 hr.
ATC Classification
C10AD06 - acipimox ; Belongs to the class of nicotinic acid and derivatives. Used in the treatment of hyperlipidemia.
References
Anon. Acipimox. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/06/2016.

Buckingham R (ed). Acipimox. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/06/2016.

Joint Formulary Committee. Acipimox. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/06/2016.

Pfizer New Zealand Ltd. Olbetam 250 mg Capsules data sheet 08 January 2014. Medsafe. http://www.medsafe.govt.nz/. Accessed 10/06/2016.

Disclaimer: This information is independently developed by MIMS based on Acipimox from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2020 MIMS. All rights reserved. Powered by MIMS.com
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