Allopac

Allopac

allopurinol

Manufacturer:

Pacific Pharma (Korea)

Distributor:

AA Medical
Concise Prescribing Info
Contents
Allopurinol
Indications/Uses
Management of primary or secondary gout; elevated serum & urinary uric acid levels in patients receiving cancer therapy.
Dosage/Direction for Use
Adult Mild gout 200-300 mg/day. Moderately severe tophaceous gout 400-600 mg/day. May be administered in divided doses (for 7300 mg) or as single dose. Max: 800 mg/day. Acute gouty attacks Initially 100 mg then 100 mg once wkly until serum uric acid levels ≤6 mg/dL.
Administration
Should be taken with food.
Contraindications
Hypersensitivity. Mild uratemia w/out symptoms (uric acid <90 mg/L). Lactation. Childn (except malignancies esp leukemia, & Lesch-Nyhan syndrome).
Special Precautions
Treatment should not be started until acute attack of gout has stopped. Hepatic impairment, renal failure. Hematopoiesis disorders. Patients on treatment for HTN or cardiac insufficiency. Maintain sufficient fluid intake. Monitor liver function tests as well as serum urate conc & urinary urate/uric acid levels. May impair ability to drive or operate machinery. Pregnancy. Elderly.
Adverse Reactions
Diarrhea, nausea; increased alkaline phosphatase & SGOT/SGPT. Acute attacks of gout. Rash, maculopapular rash.
Drug Interactions
Prolonged activity w/ 6-mercaptopurine or azathioprine. Prolonged hypoglycaemic activity w/ chlorpropamide. Increased effect of anticoagulants. Enhanced bone marrow suppression w/ cyclophosphamide & other cytotoxic agents. Enhanced toxicity of ciclosporin. Increased levels of theophylline due to inhibition of metabolism. Increased plasma t½ of vidarabine. Frequent skin rash w/ ampicillin or amoxicillin. Decreased therapeutic activity of allopurinol w/ uricosuric agents eg probenecid. Enhanced action of salicylates. Fe supplements, phenytoin, ampicillin, amoxicillin.
ATC Classification
M04AA01 - allopurinol ; Belongs to the class of preparations inhibiting uric acid production. Used in the treatment of gout.
Presentation/Packing
Form
Allopac tab 100 mg
Packing/Price
100's
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