Adult: Initially, 6.25 or 12.5 mg, may repeat after at least 2 hr if symptoms recur (2nd dose should not be taken for same attack). Max: 25 mg daily. Child: ≥12 yr Same as adult dose. Elderly: Initially, 6.25 mg.
This drug may cause dizziness, somnolence, and visual disturbance, if affected, do not drive or operate machinery.
Determine a clear diagnosis of migraine before treatment. Monitor CV status prior to initiation of treatment and periodically thereafter; hepatic and renal function.
Symptom: Somnolence, HTN or other more serious CV symptoms. Management: Symptomatic and supportive treatment. Establish a patent airway and ensure adequate oxygenation and ventilation.
Increased exposure w/ potent CYP3A4 inhibitors (e.g. ketoconazole). Potentially Fatal: May cause serotonin syndrome w/ SSRIs, SNRIs. May cause prolonged vasospastic reactions w/ ergotamine-containing drugs or other 5-HT1 receptor agonists (e.g. triptans).
Description: Almotriptan is a selective agonist of serotonin (5-HT1B/1D) receptors causing vasoconstriction of cranial arteries, reduction in transmission in trigeminal pain pathway, and inhibition of neuropeptide release. Pharmacokinetics: Absorption: Well absorbed. Bioavailability: Approx 70%. Time to peak plasma concentration: 1-3 hr. Distribution: Volume of distribution: Approx 180-200 L. Plasma protein binding: Approx 35%. Metabolism: Metabolised mainly by monoamine oxidase type A (MAOA) via oxidative deamination into indole acetic acid derivative, and to a lesser extent by CYP3A4 and CYP2D6 isoenzymes into γ-aminobutyric acid derivative. Excretion: Via urine (>75%, approx 40% as unchanged drug) and faeces (approx 13% as unchanged drug and metabolites). Plasma elimination half-life: Approx 3-5 hr.
N02CC05 - almotriptan ; Belongs to the class of selective serotonin (5HT1) agonists preparations. Used to relieve migraine.
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