Hypersensitivity to the active substance or to any of the excipients listed in Description.
Patients who develop pure red cell aplasia (PRCA) following treatment with erythropoietin should not receive Alvoetin or any other erythropoietin (see Pure Red Cell Aplasia under Precautions).
All contraindications associated with autologous blood predonation programmes should be respected in patients being supplemented with epoetin alfa.
The use of epoetin alfa in patients scheduled for major elective orthopaedic surgery and not participating in an autologous blood predonation programme is contraindicated in patients with severe coronary, peripheral arterial, carotid or cerebral vascular disease, including patients with recent myocardial infarction or cerebral vascular accident.
Surgery patients who for any reason cannot receive adequate antithrombotic prophylaxis.
Known sensitivity to Albumin (Human).