There is no well-documented experience with amlodipine overdosage. Since amlodipine absorption is slow, gastric lavage may be worthwhile in some cases. Available data suggest that gross overdosage would result in excessive peripheral vasodilation with subsequent marked and probably prolonged systemic hypotension. Clinically significant hypotension due to amlodipine overdosage calls for active cardiovascular support including monitoring of cardiac and respiratory function, elevation of extremities and attention to circulating fluid volume and urine output. A vasoconstrictor agent may be helpful in restoring vascular tone and blood pressure, provided that there is no contradiction to its use. Since amlodipine is highly protein-bound, dialysis is unlikely to be of benefit.